News Update on Blood Smear Research: April – 2019

News  Update on Blood Smear Research: April – 2019

News Update on Blood Smear Research: April – 2019

The Clinical Approach to Disorders of Platelet Number and Function

This chapter discusses the clinical approach to patients with disorders of living substance range and/or perform. As all told of clinical drugs, the history and physical examination are the keys to unlocking the identification. The characteristic clinical options that differentiate primary astringent disorders (thrombocytopenia, living substance perform defects, and Willebrand disease) from natural process disorders (e.g., hemophilia) are mentioned. 3 of those clinical options are significantly useful. First, petechiae are a really sturdy pointer towards a primary astringent disorder and far from a natural process disorder. Second, hemarthroses are a really sturdy pointer towards a natural process disorder and far from a primary astringent disorder. Third, within the setting of Associate in Nursing injury, immediate excessive hemorrhage suggests a primary astringent disorder (because the initial living substance plug doesn’t type correctly), whereas delayed hemorrhage suggests a natural process disorder (because the shortage of a grammatical protein clot leads to gradual breakdown of the initial living substance plug). [1]

Texture feature based classification on microscopic blood smear for acute lymphoblastic leukemia detection

This paper presents an efficient theme for classification of the traditional white blood cells from the affected cells during a microscopic image. The projected technique ab initio pre-processes the input pictures victimisation Y part of the CMYK image and a triangle method of thresholding. after, it utilizes distinct orthonormal S-transform (DOST) to extract the feel options, and its spatial property is reduced victimisation linear discriminant analysis. The reduced options are then equipped to the projected Adaboost algorithmic rule with RF (ADBRF) classifier wherever the random forest is employed because the base classifier. A in public obtainable dataset, ALL-IDB1 is employed to validate the projected theme. The simulation results supported the 5 runs of k-fold stratified cross-validation indicate that the projected technique yields superior accuracy (99.66%) as compared to existing schemes. [2]

Plasmodium species aware based quantification of malaria parasitemia in light microscopy thin blood smear

Malaria could be a serious worldwide sickness, caused by a bite of a feminine genus Anopheles dipterous insect. The parasite transferred into advanced life spherical during which it’s fully grown and reproduces into the shape. The detection and recognition of Plasmodium species are attainable and economical through a method known as staining (Giemsa). The staining method slightly colorizes the red blood cells (RBCs) however highlights Plasmodium parasites, white blood cells and artifacts. Giemsa stains nuclei, chromatin granule in blue tone and RBCs in pink color. it’s been reported  in varied studies that manual research isn’t a trustworthy screening technique once performed by nonexperts. protozoal infection parasites host in RBCs once it enters the blood. This paper presents segmentation of Plasmodium parasite from the skinny blood smear points on region growing and dynamic convolution based mostly filtering rule. when segmentation, plasmodium classified into four Plasmodium species: Plasmodium falciparum, Plasmodium ovale, Plasmodium vivax, and Plasmodium protozoal infection. The random forest and K‐nearest neighbor are used for classification base on native binary pattern and hue saturation price options. The sensitivity for protozoal infection blood disorder (MP) is ninety six.75% on coaching and testing of the planned approach whereas specificity is ninety four.59%. Beside these, the comparisons of the 2 options are value-added to the planned work for classification having sensitivity is eighty three.60% whereas having specificity is ninety four.90% through random forest classifier supported native binary pattern feature. [3]

Revised diagnostic criteria for plasma cell leukemia: results of a Mayo Clinic study with comparison of outcomes to multiple myeloma

The current definition of lymph cell cancer (PCL)— ≥ 20% current plasma cells (CPCs) on peripheral smear and plasma cell count ≥ 2 × 109/L—may be too rigorous. we have a tendency to reviewed outcomes of 176 myeloma (MM) patients diagnosed between 1971 and 2016, and UN agency had CPCs detectable at diagnosing, to see whether or not a lower threshold may be accustomed diagnose PCL. Median overall survival (mOS) was one.1 years (95% CI zero.8–1.4) and was similar between patients with [4]

Parasitological Screening of Haemo-Parasites of Small Ruminants in Karu Local Government Area of Nasarawa State, Nigeria

Aim: to work out the prevalence rate and severity of haemoparasitic infections in little ruminants, mistreatment age and sex as associating factors.

Study Design: This analysis study was done mistreatment sampling technique.

Place and length of Study: Karu government space abattoirs, Nasarawa State; Department of Biological Sciences, Bingham University, Karu, between Gregorian calendar month 2015 and July 2015.

Materials and Methods: 200 and sixty 5 (265) blood samples were examined microscopically at ×100 objective mistreatment oil immersion. skinny blood films were ready mistreatment Giemsa’s stain, eighty seven sheep blood samples and 178 goat blood samples were enclosed. Packed cell volume (PCV) determined mistreatment capillary tubes, Hawksley haematocrit centrifuge and reader.

Results: A considerably high prevalence rate of forty three.39% was recorded for haemoparasites of little ruminants (P [5]

Reference

[1] Michelson, A.D., 2019. The clinical approach to disorders of platelet number and function. In Platelets (pp. 701-705). Academic Press. (Web Link)

[2] Mishra, S., Majhi, B. and Sa, P.K., 2019. Texture feature based classification on microscopic blood smear for acute lymphoblastic leukemia detection. Biomedical Signal Processing and Control, 47, pp.303-311. (Web Link)

[3] Abbas, N., Saba, T., Rehman, A., Mehmood, Z., Javaid, N., Tahir, M., Khan, N.U., Ahmed, K.T. and Shah, R., 2019. Plasmodium species aware based quantification of malaria parasitemia in light microscopy thin blood smear. Microscopy research and technique. (Web Link)

[4] Revised diagnostic criteria for plasma cell leukemia: results of a Mayo Clinic study with comparison of outcomes to multiple myeloma

Praful Ravi, Shaji K. Kumar, Lindsey Roeker, Wilson Gonsalves, Francis Buadi, Martha Q. Lacy, Ronald S. Go, Angela Dispenzieri, Prashant Kapoor, John A. Lust, David Dingli, Yi Lin, Stephen J. Russell, Nelson Leung, Morie A. Gertz, Robert A. Kyle, P. Leif Bergsagel & S. Vincent Rajkumar

Blood Cancer Journalvolume 8, Article number: 116 (2018) (Web Link)

[5] Anyanwu, N. C. J., Iheanacho, C. N., & Adogo, L. Y. (2015). Parasitological Screening of Haemo-Parasites of Small Ruminants in Karu Local Government Area of Nasarawa State, Nigeria. Microbiology Research Journal International, 11(6), 1-8. https://doi.org/10.9734/BMRJ/2016/22358 (Web Link)

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