Press Release on Tumor Marker Research: April – 2019

Press Release on Tumor Marker Research: April – 2019

Press Release on Tumor Marker Research: April – 2019

Small Hepatocellular Carcinoma With Low Tumor Marker Expression Benefits More From Anatomical Resection Than Tumors With Aggressive Biology

Objective: we have a tendency to assessed prognostic advantage of anatomical operation (AR) over nonanatomical resection (NAR) for hepatocarcinoma (HCC) consistent with multiplication of α-fetoprotein, des-γ-carboxyprothrombin, and tumour volume (ADV) scores.

Background: Superiority of area unit over NAR is debated. ADV score is surrogate marker of postresection prognosis for solitary HCC.

Methods: This study enclosed 1572 patients World Health Organization underwent curative operation for solitary HCC of two.0 to 5.0 cm between 2006 and 2014.

Results: surgical patient profiles weren’t statistically totally different between area unit and NAR teams. In 1324 naïve patients while not surgical treatment, area unit cluster showed lower repetition rates (P = zero.003) and better patient survival rates (P = zero.012) than NAR cluster. area unit cluster showed lower repetition rates in patients with ADV ≤5 log (P ≤ zero.046). ADV scores >4 log and >3 log were freelance risk factors for tumour repetition and patient survival in treatment-naïve patients, severally. In treatment-naïve cluster with preserved viscus practical reserve, area unit cluster showed lower repetition rates in patients with ADV ≤4 log (P = zero.026). Absence of microvascular invasion additionally showed lower repetition rates (P = zero.007) in area unit cluster. In 248 patients with surgical treatment, area unit cluster showed lower repetition rates (P = zero.001) and better patient survival rates (P = zero.006). area unit cluster showed lower repetition rates in patients with ADV ≤4 log (P < zero.001) and better survival rates in patients with ADV ≤5 log (P ≤ zero.043).

Conclusions: Prognostic good thing about area unit was evident in patients with ADV score ≤4 log or absence of microvascular invasion. Patients with less aggressive tumour biology profit additional from area unit than NAR, therefore being fairly indicated for area unit. [1]

Highly fluorescent N-doped carbon dots with two-photon emission for ultrasensitive detection of tumor marker and visual monitor anticancer drug loading and delivery

Early diagnosing and medical aid are much necessary to effectively stop cancer and improve patients’ life quality. Herein, a straightforward and sensitive two-photon imaging fluorescent nitrogen-doped carbon dots (N-CDs) platform was created to observe β-glucuronidase (βG, a tumor-invasive biomarker) supported inner filter impact (IFE), to visually monitor metastatic tumor drug loading by light resonance energy transfer (FRET), and to effectively treat cancer by therapy. to make this sensing platform, novel N-CDs with sturdy inexperienced emission (Ca. QY = 45%) were synthesized by one-pot transmutation reaction, and specifically, careful structure style of the excitation bands of N-CDs well coated the absorption bands

of p-nitrophenol (PNP, βG chemical process product), creating it ultra-sensitive towards the activity of βG and showing smart linear relationship from one to 15 U/L and exciting detection limit of zero.3 U/L (S/N = 3). This sensing platform has been with success utilized for βG sensing in each human humor and animate thing detection. Moreover, we tend to additionally incontestible the primary application of N-CDs as a unique visual detection device to observe the loading method of antibiotic drug, and as a nanocarrier for cancer medical aid. a lot of significantly, the N-CDs additionally exhibited top quality single- and two-photon light in high depth (18 μm), facultative the N-CDs to period of time monitor the endocytosis, animate thing distribution and unharness of medication, indicating vital potential for biomedicine and bioimaging applications.[2]

Pre-orchiectomy tumor marker levels should not be used for International Germ Cell Consensus Classification (IGCCCG) risk group assignment

Purpose

To investigate whether or not the utilization of pre-orchiectomy rather than pre-chemotherapy growth marker (TM) levels has a bearing on the International reproductive cell agreement Classification (IGCCCG) risk cluster assignment in patients with pathologic process germ cell tumors (GCT).

Methods

Demographic and clinical data of all patients treated for primary pathologic process male reproductive gland non-seminomatous GCT in our tertiary care educational center were extracted from medical charts. IGCCCG risk cluster assignment was properly performed with pre-chemotherapy marker levels and in addition with pre-orchiectomy marker levels. Agreement between pre-chemotherapy and pre-orchiectomy risk cluster assignments was assessed victimisation Cohen’s letter.

Results

Our cohort consisted of eighty three patients. the utilization of pre-orchiectomy TMs resulted in Associate in Nursing IGCCCG risk cluster upstaging in twelve patients (16%, eight patients from sensible to intermediate risk and four patients from intermediate to poor risk) and a downstaging in one patient (1.2%, from intermediate- to good-risk). The agreement between pre-orchiectomy and pre-chemotherapy IGCCCG risk teams resulted during a Cohen’s letter of zero.888 (p [3]

SATB2 and CDX2 are prognostic biomarkers in DNA mismatch repair protein deficient colon cancer

DNA pair repair supermolecule deficient carcinoma ofttimes displays reduced CDX2 expression, and up to date literature has prompt that negative CDX2 expression may be a poor prognostic biomarker in carcinoma. we’ve got recently incontestable  that SATB2 is associate degree immunohistochemical marker that’s

complementary to CDX2. employing a tissue microarray approach, we have a tendency to evaluated SATB2 and CDX2 immunohistochemical expression in 514 patients with colonic glandular carcinoma together with 146 with pair repair supermolecule deficient tumors and related to expression with histopathologic variables, molecular alterations, and survival. Overall, SATB2-negative and/or CDX2-negative expression was known in thirty three of pair repair supermolecule deficient tumors compared with solely fifteenth of mismatch repair protein skilful tumors (p [4]

Role of Tumor Markers in Oral Cancer: An Overview

The oral membrane represents the primary a part of the channel and is exposed to varied exogenous toxins. Exposure for extended length will cause changes that lead to doubtless malignant diseases or cancers / Tumors. Eventually these may be diagnosed by routine histopathology, however few of them are troublesome to diagnose by this methodology alone. There arises the role of growth markers in characteristic totally different pathologies is well established. A marker may be represented as some unnoticeable object accustomed distinguish or mark bound things. largely growth markers are proteins and these markers is also detected among exfoliated or distributed cells, or as current agents among the peripheral blood or plasma. within the recent years, there’s a revived interest regarding growth markers, providing window of chance for management of cancer patients by enhancing the potency in detection and treatment set up. Recent technological advancement has enabled the examination of the many potential markers. This paper focuses on the growth markers within the head and neck neoplasm. [5]

Reference

[1] Jung, D.H., Hwang, S., Lee, Y.J., Kim, K.H., Song, G.W., Ahn, C.S., Moon, D.B. and Lee, S.G., 2019. Small hepatocellular carcinoma with low tumor marker expression benefits more from anatomical resection than tumors with aggressive biology. Annals of surgery, 269(3), pp.511-519. (Web Link)

[2] Gong, P., Sun, L., Wang, F., Liu, X., Yan, Z., Wang, M., Zhang, L., Tian, Z., Liu, Z. and You, J., 2019. Highly fluorescent N-doped carbon dots with two-photon emission for ultrasensitive detection of tumor marker and visual monitor anticancer drug loading and delivery. Chemical Engineering Journal, 356, pp.994-1002. (Web Link)

[3] Fankhauser, C.D., Gerke, T.A., Roth, L., Sander, S., Grossmann, N.C., Kranzbühler, B., Eberli, D., Sulser, T., Beyer, J. and Hermanns, T., 2019. Pre-orchiectomy tumor marker levels should not be used for International Germ Cell Consensus Classification (IGCCCG) risk group assignment. Journal of cancer research and clinical oncology, 145(3), pp.781-785. (Web Link)

[4] SATB2 and CDX2 are prognostic biomarkers in DNA mismatch repair protein deficient colon cancer

Changqing Ma, Dane Olevian, Caitlyn Miller, Cameron Herbst, Priya Jayachandran, Margaret M. Kozak, Daniel T. Chang & Reetesh K. Pai
Modern Pathology (2019) (Web Link)

[5] Lavanya, R., Mamatha, B., Waghray, S., Chaitanya, N., Reddy, M. P. and Bau, D. B. (2016) “Role of Tumor Markers in Oral Cancer: An Overview”, Journal of Advances in Medicine and Medical Research, 15(7), pp. 1-9. doi: 10.9734/BJMMR/2016/24998. (Web Link)

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