Effects of Formaldehyde on Swiss Albino Mice

Effects of Formaldehyde on Swiss Albino Mice

In a number of concentrations, formaldehyde (FA) is toxic. FA can react with lipids, proteins, and nucleic acids that are cellular components, even at lower concentrations. By harming parenchyma and degradation of functions, FA causes cellular toxic effects in the liver, lungs, kidney and brain. This research was performed to examine serum biochemical changes and the cytotoxic effects of FA toxicity in Swiss albino mice on the liver, lungs, kidneys and brain. To this end, mice were divided into four similar classes, i.e. Regulation, inhalation, intraperitoneal and oral. The exposure groups were further divided into three subgroups that were exposed to FAda daily for 30 days in the case of inhalation and oral groups and 10 days in the case of acute toxic effects in the intraperitoneal group. Samples of blood and tissue were obtained after exposure and examined for biochemical and morphological studies. Following FA exposure, serum biochemical parameters such as Aspartate Transaminase (AST) and Alanine Transaminase (ALT) were significantly increased (P ⁇ 0.05) in mice. Gross morphological changes, i.e. congestion and petechial haemorrhages of the liver, were revealed in the anatomical findings. The research revealed gross irregularities in the lungs, i.e. congestion. But in the kidney and brain, no gross abnormal features were found. Histologically, the liver displayed distributed lymphocytic infiltration, sinusoid dilatation, necrosis and parenchymal cell degeneration in orally exposed mice (10 mg/kg) and diffuse lymphocytic infiltration, and necrosis was seen in 7 and 10 mg/kg body weight in intraperitoneally FA injected mice. Lung tissue showed haemorrhages in the 5 ppm inhaled community treated. In all intraperitoneally exposed groups, Kidney showed reduced Bowman’s space in 10 mg/kg treated oral group and congestion, tubular necrosis, increased Bowman’s space. In the inhaled groups, brain tissue showed that degenerating neurons with either pycnotic or karyorrhectic nuclei were steadily increased in the highest concentration group. All these results showed that, in a dose-related way, FA has annoying toxic effects on mice.

Author(s) Details

Marya Afrin
Department of Anatomy and Histology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh, Bangladesh.

Mohammad Rafiqul Islam
Department of Anatomy and Histology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh, Bangladesh.

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