Mice were used to examine the dose-dependent effects of subacute Cr(VI) exposure on the bioenergetics of carbohydrates. The TCA cycle enzymes, blood glucose, liver glycogen, and pyruvic acid were investigated. The amount of tissue protein, free amino acid nitrogen, transaminase, and NADH dehydrogenase activity was also calculated. A dose-dependent reduction in blood glucose and hepatic glycogen was brought on by chromium exposure. Isocitrate dehydrogenase, succinate dehydrogenase, and malate dehydrogenase activities were all significantly changed according to dose. Pyruvate exhaustion was observed in hepatic tissue. Depletion of total protein, increased transaminase activity, and decreased NADH dehydrogenase activity were all linked to increased hepatic free amino nitrogen. It is concluded that Cr(VI) alters carbohydrate bioenergetics by having hypoglycaemic and glycogenolytic effects in hepatocytes that are dose-dependently accompanied by changes to the TCA cycle and electron transport pathways.

Author(s) Details:

Kanu Shil,
Nutritional Biochemistry and Toxicology Laboratory, Department of Human Physiology, Tripura University, Suryamaninagarm West Tripura – 799022, India.

Sudipta Pal,
Nutritional Biochemistry and Toxicology Laboratory, Department of Human Physiology, Tripura University, Suryamaninagarm West Tripura – 799022, India.

Please see the link here: https://stm.bookpi.org/CTCB-V5/article/view/8299

Keywords: Hexavalent chromium, hypoglycaemia, glycogenolysis, citric acid cycle, electron transport chain

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