Nanofluidic Mechanism and Computational Model of the Brain Water Metabolism

Water metabolism in the brain is specifically involved in cellular contact, the transit of signalling molecules, neurotransmitters, cytokines, and substrates, and the clearance of pathogenic metabolites, among other things. Alzheimer’s disease, idiopathic natural pressure hydrocephalus, migraine, traumatic brain injury and stroke, brain edoema, and other severe neurological disorders are all caused by abnormal brain fluid flow. At this time, the conventional hypothesis fails to account for the growing body of experimental evidence and clinical data on brain water metabolism. Modeling has become a popular method for putting existing hypotheses to the test and creating new practical mechanisms. The development and testing of a novel computational model of brain water metabolism has been completed. The brain interstitial space is regarded as a nanofluidic domain where fluid flow is controlled by nanofluidics’ slip-flow principles, according to an interdisciplinary approach. The astrocyte endfeet membranes’ aquaporin-4 (AQP4) maintains kinetic control over water movement through the blood-brain barrier. The driving force behind transcapillary water flow is pulsatory intracranial pressure. The model shows strong predictability in terms of some physiological aspects of brain water metabolism, as well as utility in describing some clinical conditions. The model may be used in neurobiological research, drug discovery for AQP4-targeted conditions, intrathecal drug delivery to brain tumours, and research on a wide range of water-metabolic-disorder-related conditions.

Author (s) Details

Ernst Titovets
Department of Neurosurgery of Republican Research and Clinical Center of Neurology and Neurosurgery, Minsk, 220114, Belarus.

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