Effect of Aqueous Leaf Extract of Ocimum gratissimum on Antiretroviral Drug-Induced Hepatotoxicity in Rats

Aim: Hepatotoxicity, among other adverse effects, constitutes one of the greatest impediments to successful antiretroviral drug therapy (ART) in HIV/AIDS patients. The main objective of the study was to determine if the aqueous leaf extract of Ocimum gratissimum has a protective effect on ART-induced hepatotoxicity in rats. Place and Duration: Department of Pharmacology, Chukwuemeka Odumegwu
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Introduction: In many parts of the world, Coffea grows between latitude 25°N and 25°S and requires specific climatic conditions to produce high bean yield and quality. In Uganda, Robusta coffee is grown in a diversity of soils that range from red sandy clay or gravelly loam to soft laterite. Macro-elements such as K, Ca and
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Aim: Results from previous studies on the effects of intake of garlic on the body antioxidant system appear inconclusive. This study measured glutathione peroxidase (GPx) and catalase (CAT) activities, Total Antioxidant Status (TAS) and selenium (Se) level in rabbits fed a high-garlic diet. Methods: Ten rabbits randomly assigned into two groups (group 1=control and group
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Introduction: The biochemical process of apoptosis may occur by a number of mechanism including; extrinsic or death-receptor pathway, intrinsic or mitochondrial-mediated pathway which involves the opening of Mitochondrial Membrane Permeability Transition (MMPT) pore in situations of intracellular calcium overload or oxidative stress or cellular insult and by the perforin/granzyme pathway. There is considerable evidence that
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The use of medicinal plants has grown all over the world. Nowadays the ethnopharmacological applications of medicinal plants are an important matter when it comes to search for new molecules with biological activity. Castanea sativa Mill is a species with great economic value since chestnut trees are an important crop in the northern region of
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This work analyses annual blocks of daily observations of pulse with arterial blood pressure (ABP) and interrelation between them. Dynamics of morning and evening parameters is compared, behavior of atmospheric pressure and geomagnetic activity is correlated. Pulse and arterial blood pressure are evaluated during periods of more active behavior of patient (expeditions, business trips, holidays,
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Background: High cost of conventional animal feed ingredients in Nigeria has made it necessary to search for alternative local sources of feed. Crop residues including sweet potato leaves abound in Nigeria. These have been explored as feed sources. The ability of microorganisms to convert agricultural wastes to more useful products could be harnessed to produce
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The way species-rich communities react over time, in both the short term (inter-annual) and the long term (decades) is usually very complicated but also often proves very instructive as regards several aspects of the functional structuration of the community. A three decades monitoring of the same butterfly community at Gariwang-san (South-Korea) thus provides interesting insights
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Aim: To investigate the phytochemicals and the anticonvulsant activity of the ethanol leaf extract of Culcasia falcifolia used in the traditional medical treatment of epilepsy. Methodology: The phytochemical screening was carried out using standard protocol while the anticonvulsant activity was studied using Pentylenetetrazole in mice. Result: The preliminary phytochemical screening carried out on the ethanol
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It is estimated that there will be an increase in the incidence of chronic obstructive pulmonary disease (COPD) in the coming decades. Thus, the pharmacological attributes of products of plant origin should be considered as an important economic and scientific strategy in the investigation of therapeutic alternatives, since their experimental validations are indispensable to substantiate
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