Flupirtine: An Exigency Call for Medication Vigilant

The purpose of this monograph is to provide an extensive review of the drug Flupirtine clinical applications and its safety-related issues. While existing Non- Steroidal Anti-inflammatory Drugs (NSAIDs) and Opioids which are used in the treatment of pain had some common adverse effects this drug is devoid of adverse effects exhibited by NSAIDs and Opioids
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MicroRNA-221/222 (miRNA-221/222, miR-221/222) is non-coding microRNA which widely distributed in eukaryotic organisms, and deeply involved in the post-transcriptional regulation of gene expressions. According to recent studies, abnormal expressions of miR-221/222 are closely related to the occurrence and development of various kinds of malignant tumors. The role of miR-221/222 in tumor development and their potential molecular
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Cancer traditionally is viewed through the lens of the biomedical model. It has been suggested that a broader theoretical framework with psychosocial components related to the development of cancer is needed to provide a complementary perspective. The purpose here is to explore the utility of attachment theory as a biopsychosocial model of both development and
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In developed and westernized countries such as the United States, endometrial cancer (EC) is the most common gynecological cancer with incidence rates being as much as 10 times higher than other cultures. The majority of women present with postmenopausal and abnormal perimenopausal bleeding, and almost 75% of these patients are in the early disease stage,
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Mesenchymal stem cells (MSCs) are a kind of somatic stem cells that exert a potential to differentiate into multiple cell types and undergo robust clonal self-renewal, therefore they are considered as a highly promising stem cell population for the tissue engineering. MSCs are identified in various adult organs including dental tissues. Periodontal ligament (PDL) is
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Background: To cure ischemic diseases, angiogenesis needs to be improved by various strategies in ischemic area. Considering that microRNA-132 (miR-132) regulates endothelial cell behavior during angiogenesis and the safe and efficacious delivery of microRNAs in vivo is rarely achieved, an ideal vehicle for miR-132 delivery could bring the promise for ischemic diseases. As a natural
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Pain is the most distressing and incapacitating symptom experienced by cancer patients. While mindfulness-based stress reduction (MBSR) interventions have been conducted with cancer patients, no study has explored psychological and pain-related factors in patients with cancer-related pain. The effects of an eight-week MBSR intervention were investigated on pre-post scores for pain catastrophizing, pain-related anxiety, pain
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A 25-year-old woman presented with acute urine retention with overflow 6 months after an inadequate treatment of severe monilia infections. Examination revealed complete adhesion between both labia majora. Division of adhesion was done with reconstruction by labial flap. Complete recovery was achieved with good cosmetic outcome. Conclusion: Labial adhesions whatever their severity is can be
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The current overly broad definition of autism has launched an epidemic of false diagnoses that include conditions of uncertain similarities. Professionals diagnose by ticking off symptoms on a subjective checklist that has no clear relation to causality. This study firmly establishes that autism has a singular neurophysiological cause that is responsible for all 52 of
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Plants produce a diverse range of bioactive molecules, making them rich source of different types of medicines. The medicinal value of plants lies in some chemical substances that produce a definite physiological action on the human body. In this study, we explored the efficacy of methanol, chloroform and petroleum ether extracts of two traditionally used
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