5-[Substituted]-1, 3, 4-thiadiazol-2-amines: Synthesis, Spectral Characterization, and Evaluation of their DNA Interactions

5-[Substituted]-1, 3, 4-thiadiazol-2-amines: Synthesis, Spectral Characterization, and Evaluation of their DNA Interactions

One of the most important aspects of the manufacture of medicinal drugs is the synthesis of novel thiadiazoles. Current medicinal chemistry research has focused on the properties of new compounds with possible novel structural features and biological applications. In this context, the synthesis and characterization of 5-[substituted]-1, 3, 4-thiadiazol-2-amines are presented (1-7). Spectroscopic methods such as 1H-NMR, 13C1H-NMR, FT-IR, and LC-MS were used to classify all of the prepared compounds. Absorption and fluorescence spectroscopy were used to investigate the 1,3,4-thiadiazoles’ DNA binding interactions. The findings show that the compounds are strong DNA binders. Mode of groove binding. The compounds’ DNA cleavage was investigated using gel electrophoresis in the presence and absence of H2O2.

Author (s) Details

Dr. P. Murali Krishna
Department of Chemistry, Ramaiah Institute of Technology, Bangalore – 560054, India.

Dr. N. Shivakumara
Department of Chemistry, Ramaiah Institute of Technology, Bangalore – 560054, India.

View Book :- https://stm.bookpi.org/CPCS-V9/issue/view/44

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