Although the possible side effects of antioxidants have not been properly evaluated or understood, the escalating use of antioxidant supplements has been challenged repeatedly. This study offers a detailed insight into the literature looking for possible targets in tissues and cells for antioxidants, with which they can interact to produce their toxic effects. Oxidants are cellular components that in cancer cells drive certain cellular main metabolic processes, and in the same cells they seem to weaken certain other metabolic pathways. By reducing apoptotic pathways and increasing energy output from glycolysis, excess deactivation by antioxidants can boost cellular survival. In addition, oxidants are essential immune reactivity factors, as well as immune cell metabolic activators that perform anti-microbial and anti-tumor activities, so the abolition of oxidant activity can hinder these vital functions. It is hypothesized that excessive intake of antioxidants will disturb the vital balance of oxidants-antioxidants, creating a new state of antioxidant stress, leading to enhanced cancer cell growth and weakened immunity. For the clinical case, a vital balance of antioxidant intake needs to be determined. Moreover, the possible molecular pathways that may contribute to this stress have been extensively investigated.
Author (s) Details
Fawwaz S. Al Joudi
Biotechnology Program, Faculty of Engineering, McMaster University, 1280 Main St, Hamilton, Ontario L8S 4L8, Canada.
View Book :- https://stm.bookpi.org/CACB-V2/issue/view/16