Eco-friendly and Green Synthesis of 2-alkylsulfanyl3H-quinazolin-4-one
Reaction of 2-Thioquinazolinone (1) with various alkylating agents like dimethyl sulphate (DMS), diethyl sulphate (DES) and benzyl chloride (PhCH2Cl) in the presence of K2CO3 as a mild base, by a simple physical grinding, microwave irradiation, and PEG-600 under solvent-free conditions for 10-15 min at RT, followed by processing, gave respectively 2-methylsulfanyl-3H-quinazolin-4-one (2a, i.e., R=CH3), 2-ethylsulfanyl-3H-quinazolin-4-one (2b, i.e., R=C2H5) and 2-benzyl sulfanyl-3H-quinazolin4-one (2c, i.e., R=PhCH2Cl). It appears from this study that Green syntheses such as solid phase synthesis (physical Grinding) and Micro wave Irradiation gives better yields, quality and in less reaction time the products over conventional methods involving green solvents like ethanol, PEG-600 etc. The entire sequences of reactions have been carried out using eco-friendly solvents and green conditions.
Dr. Srinivasa Reddy Bireddy
Department of Chemistry, Mahatma Gandhi Institute of Technology, Gandipet, Hyderabad, (T.S.) 500 075, India.
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