Organoiodine(V) Reagents in Organic Synthesis

Organohypervalent iodine reagents have attracted significant recent interest as versatile and environmentally benign oxidants with numerous applications in organic synthesis. This Perspective summarizes synthetic applications of hypervalent iodine(V) reagents: 2-iodoxybenzoic acid (IBX), Dess−Martin periodinane (DMP), pseudocyclic iodylarenes, and their recyclable polymer-supported analogues. Recent advances in the development of new catalytic systems based on the generation of hypervalent iodine species in situ are also overviewed.[1]

New Generation of Biocatalysts for Organic Synthesis

The use of enzymes as catalysts for the preparation of novel compounds has received steadily increasing attention over the past few years. High demands are placed on the identification of new biocatalysts for organic synthesis. The catalysis of more ambitious reactions reflects the high expectations of this field of research. Enzymes play an increasingly important role as biocatalysts in the synthesis of key intermediates for the pharmaceutical and chemical industry, and new enzymatic technologies and processes have been established. Enzymes are an important part of the spectrum of catalysts available for synthetic chemistry. The advantages and applications of the most recent and attractive biocatalysts—reductases, transaminases, ammonia lyases, epoxide hydrolases, and dehalogenases—will be discussed herein and exemplified by the syntheses of interesting compounds.[2]

New tools and concepts for modern organic synthesis

The increasing need to efficiently assemble small molecules as potential modulators of therapeutic targets that are emerging from genomics and proteomics is driving the development of novel technologies for small-molecule synthesis. Here, we describe some of the general applications and approaches to synthesis using one such technology — solid-supported reagents — that has been shown to significantly improve productivity in the generation of combinatorial libraries and complex target molecules.[3]

Synthesis of 3-azoindoles

Azo compounds are an important class of organic colorants which consist of a conjugated chromophore azo (-N=N-) group in association with one or more aromatic or heterocyclic systems]. Azo dyes based on heterocyclic amines have higher tinctorial strength and give brighter dyeing than those derived from aniline based diazo components. Literature survey reveals that not much work has been done on N-alkyl 3-azoindoles and their pharmacological activity. It has been considered worthwhile to synthesise N-methyl-3-azoindoles as part of our ongoing research on the development of novel synthetic route for pyrrolo(3,2-b)indoles. We herein report a simple procedure for the synthesis of 3-azoindoles.[4]

Green and Environmentally Benign Organic Synthesis by Using Fruit Juice as Biocatalyst: A Review

Facile and green synthetic approaches are important issues in organic synthesis. Green chemistry has become a motivational and inspirational tool for organic chemists to develop mild and benign pathways for the synthesis of biologically active compounds. The naturally available fruit juice as a biocatalyst in synthesis fulfills almost all the terms and conditions of green chemistry and attracted the interest of researchers. The best thing is that most of fruits are easily available, cheap and can be easily extracted. The purpose of this review is to look out present aspects of fruit juice in organic transformations.[5]


Reference

[1] Zhdankin, V.V., 2011. Organoiodine (V) reagents in organic synthesis. The Journal of organic chemistry, 76(5), pp.1185-1197.

[2] Nestl, B.M., Hammer, S.C., Nebel, B.A. and Hauer, B., 2014. New generation of biocatalysts for organic synthesis. Angewandte Chemie International Edition, 53(12), pp.3070-3095.

[3] Ley, S.V. and Baxendale, I.R., 2002. New tools and concepts for modern organic synthesis. Nature Reviews Drug Discovery, 1(8), pp.573-586.

[4] Suhana, H., Arthanareeswari, M. and Kamaraj, P., 2014. Synthesis of 3-azoindoles. International Research Journal of Pure and Applied Chemistry, pp.292-298.

[5] Gulati, S. and Singh, R., 2018. Green and Environmentally Benign Organic Synthesis by Using Fruit Juice as Biocatalyst: A Review. International Research Journal of Pure and Applied Chemistry, pp.1-15.

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