Latest Research News on Polylactic Acid Research: Sep – 2019

Polylactic Acid Technology

Polylactic acid is proving to be a viable different to petrochemical‐based plastics for several applications. it’s made from renewable resources and is perishable, mouldering to convey liquid, CO2, and humus, the black material in soil. additionally, it’s distinctive physical properties that create it helpful in numerous applications together with paper coating, fibers, films, and packaging (see Figure). [1]

POLYLACTIC ACID FOR SURGICAL IMPLANTS

High relative molecular mass compound from carboxylic acid are often made up of the cyclic lactide intermediate, appropriate for casting films or spinning fibers. The films are definite quantity leaky to vapor and might soften in presence of water. histologic studies indicate that the polylactic acid is non-toxic, nontissue reactive, and perishable, as proven any by the study of degradation of C14 labeled  compound in vivo. The degradation studies additionally show that the compound or its degradation product aren’t maintained in any of the important organs of the animals. The compound implant, however, degrades slowly in vivo, losing 12-14% in 3 months. This study indicates polylactic acid to be a really appropriate material for sutures, tube grafts, and different surgical implants. [2]

Sterilization, toxicity, biocompatibility and clinical applications of polylactic acid/ polyglycolic acid copolymers

This is a review of salient studies of sterilization, toxicity, biocompatibility, clinical applications and current add the sphere of medical science, victimisation implants manufactured from polylactic acid (PLA), polyglycolic acid (PGA) and their copolymers. The intrinsic nature of those biomaterials renders them appropriate for applications wherever temporally slow releases of bioactive agents in place is also needed. they’re conjointly fascinating as fixation devices of bone, as a result of they will nearly eliminate osteopenia related to stress shielding or further surgery. the bulk of presently obtainable sterilization techniques don’t seem to be appropriate for these thermoplastic materials and it should be fascinating to develop new sterilization standards, which may account for the special character of PLA-PGA materials. [3]

Efficacy and safety of a newly developed polylactic acid microsphere as an injectable bulking agent for penile augmentation: 18-months follow-up

Polylactic acid (PLA) fillers are wide used for cosmetic volume augmentation. But, no study has evaluated the utilization of PLA filler in penial augmentation (PA No. 4). we have a tendency to evaluated the effectuality and safety of a freshly developed PLA filler for PA throughout a 18-month follow-up amount. a complete of twenty three healthy adult men were prospectively registered between June and November 2012. penial girth was measured at proximal-, mid- and distal-shaft at baseline, 3, 6, twelve and eighteen months following injection. Subjects’ satisfaction was assessed with visual analogue scale (VAS). Adverse events (AEs) were additionally according. Mean injected volume was 20 ml. [4]

Effect of Composition Variation on the Tensile Strength of Polylactic Acid Reinforced with Natural Polymers for Biodegradable Biomedical Implants

Aims: This analysis focuses on developing a mix of natural polymers appropriate for medical specialty implants with commonplace mechanical (tensile) properties, compatible and expendable with material body

Study Design: This analysis developed a chemical compound composite from a mix of the 3 natural chemical compound materials with totally different compositions that may adequately replace non-biodegradable implants.

Place and length of Study: The analysis was conducted at the department of commercial and production engineering and department of scientific discipline and material engineering federal university of technology akure Nigeria between 2017 and 2018. [5]

Reference

[1] Drumright, R.E., Gruber, P.R. and Henton, D.E., 2000. Polylactic acid technology. Advanced materials, 12(23), (Web Link)

[2] Kulkarni, R.K., Pani, K.C., Neuman, C. and Leonard, F., 1966. Polylactic acid for surgical implants (No. AMBRL-TR-6608). WALTER REED ARMY MEDICAL CENTER WASHINGTON DC ARMY MEDICAL BIOMECHANICAL RESEARCH LAB. (Web Link)

[3] Athanasiou, K.A., Niederauer, G.G. and Agrawal, C.M., 1996. Sterilization, toxicity, biocompatibility and clinical applications of polylactic acid/polyglycolic acid copolymers. Biomaterials, 17(2), (Web Link)

[4] Efficacy and safety of a newly developed polylactic acid microsphere as an injectable bulking agent for penile augmentation: 18-months follow-up
D Y Yang, K Ko, S H Lee, D G Moon, J W Kim & W K Lee
International Journal of Impotence Researchvolume 29, pages136–141 (2017) (Web Link)

[5] Gideon, O. and Wisdom, S. (2018) “Effect of Composition Variation on the Tensile Strength of Polylactic Acid Reinforced with Natural Polymers for Biodegradable Biomedical Implants”, Journal of Materials Science Research and Reviews, 2(2), (Web Link)