Mono, Bi and Trihetercyclic Compounds: Synthesis, Characterization, Physicochemical, Structural and Biological Properties

Mono, Bi and Trihetercyclic Compounds: Synthesis, Characterization, Physicochemical, Structural and Biological Properties

The synthesis of new mono-, bi- and tri-heterocyclic carboxylic and phosphonic acid models are attracting the interest of research teams around the world due to the broad spectrum of activity they present. Indeed, these biomolecules constitute a class of compounds active in biochemistry, enzymology, medicine, agrochemical industry, and pharmacology. The Professors and Researchers, members of the Organic Chemistry Laboratory, aware of the importance of integrating the University into its socio-economic environment and of the interest in linking their fundamental research axes to the world of industry, have turned to themes, at the chemistry-biology interface, focused on the search for molecules with agrochemical, pharmaceutical, and therapeutic potential. In addition to these properties, these molecules have several reactive centers and can be involved in different reactions, very important steps in the formation of the organic chemist. This book covers key areas of heterocyclic chemistry. It is based on four pillars: (1) the extension of our previous work on heterocyclic alkylation and cycloaddition reactions to the preparation of new models of heterocyclic and phosphonic amino acids by the substitution reaction of O-tosyl group and azide derivatives by different amino acids with heterocyclic and non-heterocyclic chains (glycine, proline, histidine, tryptophan…); (2) the application of the synthesis strategy provided for in the first part to the synthesis of new mono-, bi- and tri-heterocyclic carboxylic and phosphonic models; (3) the use of spectroscopic methods (NMR 1H, 13C, 14N, 1D, 2D, IR) and analytical techniques (X-ray diffraction, mass, elemental analysis) for the characterization of the synthesized molecules, (4) the search for an application to the synthesized molecules.

Author (s) Details

Anouar Alami
Laboratory of Organic Chemistry (LCO), Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, FES, Morocco.

Younas Aouine

Laboratory of Organic Chemistry (LCO), Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, P.B. 2626, Fez 30000, Morocco and Department of Chemistry, Faculty of Sciences, Ibn Zohr University, P.B. 8106, Cité Dakhla, Agadir 80060, Morocco.

Brahim Labriti

Laboratory of Organic Chemistry (LCO), Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, P.B. 2626, Fez 30000, Morocco.

Hassane Faraj

Laboratory of Organic Chemistry (LCO), Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, P.B. 2626, Fez 30000, Morocco.

Abdelilah El Hallaoui

Laboratory of Organic Chemistry (LCO), Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, P.B. 2626, Fez 30000, Morocco.

Salaheddine Boukhssas

Doctoral Training “Bioactive Molecules, Health and Biotechnology”, Center of Doctoral Studies “Sciences and Technology”, Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, P.B. 2626, Fez 30000, Morocco and Laboratory of Organic Chemistry (LCO), Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, P.B. 2626, Fez 30000, Morocco.

Khadim Dioukhane

Doctoral Training “Bioactive Molecules, Health and Biotechnology”, Center of Doctoral Studies “Sciences and Technology”, Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, P.B. 2626, Fez 30000, Morocco and Laboratory of Organic Chemistry (LCO), Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, P.B. 2626, Fez 30000, Morocco.

Sara Hajib

Doctoral Training “Bioactive Molecules, Health and Biotechnology”, Center of Doctoral Studies “Sciences and Technology”, Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, P.B. 2626, Fez 30000, Morocco and Laboratory of Organic Chemistry (LCO), Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, P.B. 2626, Fez 30000, Morocco.

Oumaima Karai

Laboratory of Organic Chemistry (LCO), Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, P.B. 2626, Fez 30000, Morocco.

Abdou Khadir Fall

Laboratory of Organic Chemistry (LCO), Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, P.B. 2626, Fez 30000, Morocco.

Khalid Boukallaba

Laboratory of Organic Chemistry (LCO), Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, P.B. 2626, Fez 30000, Morocco.

 

View Book: – http://bp.bookpi.org/index.php/bpi/catalog/book/163

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