News Update on Heterocyclic Compounds Research: Sep – 2019

News Update on Heterocyclic Compounds Research: Sep – 2019

News Update on Heterocyclic Compounds Research: Sep – 2019

Recent Advances in Solution-Phase Multicomponent Methodology for the Synthesis of Heterocyclic Compounds

Following the raised interest from the pharmaceutical business for the generation of various libraries of heterocyclic compounds, scientific efforts became a lot of and a lot of targeted on the event of novel multi-component procedures as a way of gaining fast access to such compounds. Initially, the event of solid-phase procedures received hefty attention. However, current efforts square measure progressively involved with the event of solution-phase procedures. The latter are the topic of debate during this review, that aims to administer an summary of the progress created within the past decade.

After a general introduction, non-catalyzed, acid-catalyzed, and transition metal-catalyzed solution-phase multi-component procedures for the preparation of a good vary of heterocycles are mentioned. The last chapter discusses the role of cycloaddition reactions within the development of novel MCRs for the synthesis of heterocyclic compounds. [1]

Nickel-phosphine complex-catalyzed Grignard coupling—II : Grignard coupling of heterocyclic compounds

A general, versatile methodology for alkylation and arylation of haloheterocyclic compounds is reported . within the presence of a chemical change amount of [NiCl2(dppp)], wherever dppp stands for Ph2P(CH2)3PPh2, bromothiophenes, halopyridines, haloquinoline, and haloisoquinolines reacted with alkyl radical and aryl Grignard reagents at temperature or at ether refluxing temperature to present the cross-coupling product. The coupling reaction has been applied to the synthesis of isoquinoline alkaloids. Reactivities of 2-thienyl and 2-pyridyl Grignard reagents have conjointly been examined. [2]

Heterocyclic compounds

The present invention relates to a heterocycle of the subsequent general formula (I): wherein X is sulfur atom, chemical element atom or —NR3— (R3 could kind a heterocycle or a substituted heterocycle with R1 via the atomic number 7 atom), R1 is radical, substituted radical, aryl group, substituted aryl cluster, heterocyclic cluster or substituted heterocyclic cluster, and R2 is atom, group atom etc.; or its pharmaceutically acceptable salt and antiviral inducers, antiviral agents, malignant tumor agents and therapeutic agents for immunological diseases comprising the compound (I) or its pharmaceutically acceptable salt as active ingredients. [3]

Application of Hydrazine-Embedded Heterocyclic Compounds to High Voltage Rechargeable Lithium Organic Batteries

Hydrazine-embedded heterocyclic compounds with dimeric dimethylacridine (1b), carbazole (2b), and thiazine (3b) skeletons were applied to cathode active materials of reversible metal organic batteries, and also the performance of the batteries was evaluated. The charge/discharge curves exhibited clear plateaus within the high voltage vary of three.3–3.7 V. The capacities of the highland regions were such as the calculated capacities corresponding to the one-electron chemical reaction of the molecules. the quantity of the active compound 3b may well be enhanced up to 30 wt% within the conductor composite, and quick charge/discharge performance was additionally ascertained. [4]

Synthesis of Co2+/Zn2+ Impregnated Bentonite-Chitosan Composite Hetero-catalyst and Application of Principal Component Analysis to Evaluate its Catalytic Activity for the Synthesis of Nitrogen Containing 5 and 6 Membered Heterocyclic Compounds

A hetero-catalyst, Co2+ and Zn2+ fertilised Bentonite-Chitosan composite (Co2+-BCC and Zn2+-BCC) has been developed on an individual basis and characterised mistreatment scanning microscope (SEM), for the synthesis of a unique category of atomic number 7 containing five and vi four-membered heterocyclic compounds. Co2+-BCC showed high chemical change activity for octahydroquinazolinones and imidazoles; and Zn2+-BCC for one,4-dihydropyridines and benzimidazoles. Isoxazoles were synthesized in glorious yield by each Co2+-BCC and Zn2+-BCC. totally different ratios of Co2+/Zn2+-BCC were analyzed to realize high share yield of heterocyclic compounds. [5]

Reference

[1] Orru, R.V. and de Greef, M., 2003. Recent advances in solution-phase multicomponent methodology for the synthesis of heterocyclic compounds. Synthesis, 2003(10), pp.1471-1499. (Web Link)

[2] Tamao, K., Kodama, S., Nakajima, I., Kumada, M., Minato, A. and Suzuki, A.K., 1982. Nickel-phosphine complex-catalyzed Grignard coupling—II: Grignard coupling of heterocyclic compounds. Tetrahedron, 38(22), pp.3347-3354. (Web Link)

[3] Kurimoto, A., Ogino, T. and Kawakami, H., Sumitomo Pharmaceuticals Co Ltd and Japan Energy Corp, 2001. Heterocyclic compounds. U.S. Patent 6,329,381. (Web Link)

[4] Application of Hydrazine-Embedded Heterocyclic Compounds to High Voltage Rechargeable Lithium Organic Batteries
Takeshi Shimizu, Koji Yamamoto, Palash Pandit, Hirofumi Yoshikawa & Shuhei Higashibayashi
Scientific Reportsvolume 8, Article number: 579 (2018) (Web Link)

[5] Agarwal, D., Dhanik, J., Verma, A. and Kumar Kasana, V. (2018) “Synthesis of Co2+/Zn2+ Impregnated Bentonite-Chitosan Composite Hetero-catalyst and Application of Principal Component Analysis to Evaluate its Catalytic Activity for the Synthesis of Nitrogen Containing 5 and 6 Membered Heterocyclic Compounds”, International Research Journal of Pure and Applied Chemistry, 16(3), pp. 1-12. doi: 10.9734/IRJPAC/2018/41446. (Web Link)

Editor 251News

leave a comment

Create Account



Log In Your Account



WP2Social Auto Publish Powered By : XYZScripts.com