News Update on Oxide Nanoparticle: March – 2020

News Update on Oxide Nanoparticle: March – 2020

Iron Oxide Nanoparticle Platform for Biomedical Applications

Progress in nanosynthesis has succeeded in making nanoscale particles from iron oxide under precise quality control. Given the recent great advances in polymer manufacturing, antibody purification, DNA/RNA synthesis and magnetic resonance imaging (MRI), such iron oxide nanoparticles (IONPs) have been enriched with many variables and attracted great interest in studying their potential biomedical applications. After nearly two decades’ effort, IONPs have become a powerful platform in many diverse aspects of biomedicine, including MRI, gene and drug delivery, and hyperthermia. While some studies are still at the proof-of-concept stage, others have now been widely used in clinics. With the on-going efforts to enhance their targeting ability and endow more functions, IONPs’ future applications are highly expected. [1]

Nanotoxicity of iron oxide nanoparticle internalization in growing neurons

Magnetic nanoparticles (MNPs) have shown great promise for use as tools in a wide variety of biomedical applications, some of which require the delivery of large numbers of MNPs onto or into the cells of interest. [2]

Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging

The field of molecular imaging has recently seen rapid advances in the development of novel contrast agents and the implementation of insightful approaches to monitor biological processes non-invasively. [3]

The Toxicity of Gold, Silver, and Zinc Oxide Nanoparticles on LDH Enzyme in Male Mice

Aims: Nanoparticles have the potential to be used in medical imaging, disease diagnosis, cancer treatment and other procedures. These nanoparticles accumulate in the body tissues and result in oxidative stress with the generation of reactive oxygen species. This study investigates the effects of gold, silver, and zinc oxide nanoparticles on the LDH enzyme in male mice. [4]

Characteristics of Penicillin G Acylase Immobilized onto Iron Oxide Nanoparticles

Penicillin G acylase was immobilized onto iron oxide nanoparticles coated with polyethyleneimine and then cross linked with glutaraldehyde solution. The FTIR spectrum of immobilized enzyme showed peak at 1648cm-1 which can be attributed to the C=N bonds of Schiff’s base linkage formed between glutaraldehyde and amino group of penicillin G acylase. By considering the FTIR spectrum of nano particle coated with polyethyleneimine, adsorption of penicillin G acylase has taken place and then glutaraldehyde cross linked enzyme onto activated support. Catalytic properties of nano penicillin G acylase were improved upon immobilization [5]

Reference

[1] Xie, J., Huang, J., Li, X., Sun, S. and Chen, X., 2009. Iron oxide nanoparticle platform for biomedical applications. Current medicinal chemistry16(10), pp.1278-1294.

[2] Pisanic II, T.R., Blackwell, J.D., Shubayev, V.I., Fiñones, R.R. and Jin, S., 2007. Nanotoxicity of iron oxide nanoparticle internalization in growing neurons. Biomaterials28(16), pp.2572-2581.

[3] Thorek, D.L., Chen, A.K., Czupryna, J. and Tsourkas, A., 2006. Superparamagnetic iron oxide nanoparticle probes for molecular imaging. Annals of biomedical engineering34(1), pp.23-38.

[4] Negahdary, M. and Ajdary, M. (2014) “The Toxicity of Gold, Silver, and Zinc Oxide Nanoparticles on LDH Enzyme in Male Mice”, Annual Research & Review in Biology, 4(8), pp. 1346-1352. doi: 10.9734/ARRB/2014/5370.

[5] Bahman, M.S., Mohammad, A.S., Akbarzadeh, A., Mona, S., Gigloo, S.H., Ali, F. and Dariush, N., 2013. Characteristics of Penicillin G Acylase Immobilized onto Iron Oxide Nanoparticles. Biotechnology Journal International, pp.367-376.

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