Synthesis and Characterization of N-((tetrazol-5 yl)methyl)cyclohexanamine through 2D NMR Experiments: An Overview| Chapter 10 | Theory and Applications of Chemistry Vol. 4

Synthesis and Characterization of N-((tetrazol-5 yl)methyl)cyclohexanamine through 2D NMR Experiments: An Overview| Chapter 10 | Theory and Applications of Chemistry Vol. 4

Tetrazoles are an important class of nitrogen containing heterocycles with a wide range of medicinal and commercial applications. Tetrazolyl analogs of amino acids exhibit versatile biologic activity, and some of them are known pharmaceuticals. In addition, compounds of this type may be using in development of radiopharmaceuticals for positron emission tomography.

In continuation of our investigations in the tetrazolic amino acids, we described in this presentation the synthesis and characterization of some aminoalkyl and tetrazolic amino acid derivatives basing on different spectroscopic methods as NMR 2D.

A simple synthetic approach to N-((tetrazol-5-yl)methyl)cyclohexanamine in two steps starting from chloroacetonitrile and cyclohexylamine is reported. The synthesized compound was characterized by 2D NMR spectroscopy (1H, 13C) and elemental analysis data.

 

Author(s) Details

Hassane Faraj

Organic Chemistry Laboratory (LCO), Faculty of Sciences Dhar Mahraz, Sidi Mohammed Ben Abdellah University, P.B. 2626, Fez 30000, Morocco.

Abdelilah El Hallaoui

Organic Chemistry Laboratory (LCO), Faculty of Sciences Dhar Mahraz, Sidi Mohammed Ben Abdellah University, P.B. 2626, Fez 30000, Morocco.

 

View Book: http://bp.bookpi.org/index.php/bpi/catalog/book/149

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