Oral Cancer and Precancerous Lesions
In the United States, cancers of the oral cavity and oropharynx represent approximately three percent of all malignancies in men and two percent of all malignancies in women. The American Cancer Society estimates that 28,900 new cases of oral cancer will be diagnosed in 2002, and nearly 7,400 people will die from this disease. Over 90 percent of these tumors are squamous cell carcinomas, which arise from the oral mucosal lining. 
Epidemiology and prevention of oral cancer
Descriptive epidemiology of oral and pharyngeal cancer over the last four decades is reviewed, with specific focus on Europe. Substantial rises in mortality rates have been observed for younger males, mostly in eastern Europe. The independent role of alcohol and tobacco and their interaction on oral carcinogenesis is discussed, since these factors account for about three quarters of oral cancers in Europe. 
Human Papillomavirus and Oral Cancer: The International Agency for Research on Cancer Multicenter Study
Background: Human papillomavirus (HPV), the causal agent of cervical cancer, appears to be involved in the etiology of cancer of the oral cavity and oropharynx. To investigate these associations, we conducted a multicenter case-control study of cancer of the oral cavity and oropharynx in nine countries. Methods: We recruited 1670 case patients (1415 with cancer of the oral cavity and 255 with cancer of the oropharynx) and 1732 control subjects and obtained an interview, oral exfoliated cells, and blood from all participants and fresh biopsy specimens from case patients. 
Role of Tumor Markers in Oral Cancer: An Overview
The oral mucosa represents the first part of the digestive tract and is exposed to various exogenous toxins. Exposure for longer duration can lead to changes that lead to potentially malignant diseases or cancers / Tumors. Eventually these can be diagnosed by routine histopathology, but few of them are difficult to diagnose by this method alone. 
Novel Therapy for Oral Cancer – Gene Therapy an Update
Gene therapy provides modern medicine with new perspectives and had great potential as a novel therapeutic modality. Progress in molecular biology, especially molecular medicine is now changing the basics of genetic disease. This technology takes advantage of our understanding of cancer at the molecular level. It has been exploited to develop new strategies for killing cells selectively or arresting their growth. This is new technique, being developed which offers incredible pledge for the upcoming therapeutic modality in oral cancer treatment. The aim of this paper is to review delivery routes, vector design, therapeutic applications and possible obstacles faced by gene therapist. 
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