Determining the Practical Synthesis and Purification of cis-11-Octadecenoic Acid: A Component of Inhibition of Endotoxin Response

This research focuses on the practical and efficient synthesis of 1 with the goal of producing a high purity version of this valuable molecule. The chemical cis-11-octadecenoic acid 1 was synthesised using a Wittig reaction with n-heptanal and 10-methoxycarbonyldecyltriphenylphosphonium bromide using potassium t-butoxide at –50°C to give methyl cis-11-octadecenoate 2 in 79 percent yield with 95 percent cis-selectivity, followed by hydrolysis .

Author(S) Details

Yoshifumi Yuasa
Kasai Chemical Laboratory, 7-7-402 Akashicho, Hiratsuka, Kanagawa, 254-0042, Japan.

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