A Descriptive Study on Preparation and Characterization of Keratin/Alginate Blend Microparticles

A Descriptive Study on Preparation and Characterization of Keratin/Alginate Blend Microparticles

Because of their greater environmental protection than synthetic materials, the analysis of protein materials such as collagen, gelatin, albumin, and silk fibroin and keratin has been increasingly increased. For the production of keratin (Ker), alginate (Alg), and Ker/Alg blend microparticles, the water-in-oil (W/O) emulsification-diffusion method was used. The solutions of the Ker, Alg, and Ker/Alg blend were used as the water phase, while the oil phase was used with ethyl acetate. Firstly, to find appropriate material, various concentrations of the Ker solution were used. For further microparticle construction, 1.6 percent w/v Ker solution was blended with the same Alg solution concentration. Scanning electron microscope research findings indicate that the microparticles have various shapes: spherical, bowl-like, porous, and hollow, depending on the blend ratio, with many sizes. FTIR and TG studies suggested that the Ker/Alg blend ratio was influenced by the secondary structure and thermal stability of the microparticles. The relationship between keratin and alginate functional groups was the key factor for both β-sheet Structure and microparticles Td,max values. The results indicated that by adjusting the Ker/Alg ratio, Ker/Alg blend microparticles could be used in several fields. The microparticles obtained from this work are promising for the loading and delivery of both hydrophobic and hydrophilic functional molecules through the blood circulation system to the target organ.

Author (s) Details

Yaowalak Srisuwan
Creative and Innovation Chemistry Research Unit, The Center of Excellence for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Mahasarakham University, Maha Sarakham 44150, Thailand.

Prasong Srihanam
Creative and Innovation Chemistry Research Unit, The Center of Excellence for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Mahasarakham University, Maha Sarakham 44150, Thailand.

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