A Narrative Review on the Effect of Acetaminophen and Ibuprofen in Orthodontic Tooth Movement

A Narrative Review on the Effect of Acetaminophen and Ibuprofen in Orthodontic Tooth Movement

Application of orthodontic force causes an inflammatory event resulting in bone resorption and subsequent orthodontic tooth movement (OTM) in the periodontium. The release of inflammatory mediators such as E2 prostaglandins and Interleukin-1β serve as potent bone resorption stimulators. Strong force application results in discomfort and the same non-steroidal anti-inflammatory medications (NSAIDs) are recommended for relief. By interfering with prostaglandin (PG) synthesis, these NSAIDs negate the inflammatory reactions, thereby inhibiting orthodontic tooth movement. The aim of this mini literature review was to highlight the impact on their pain relieving capacity and effect on OTM of the two widely used medications, namely acetaminophen and ibuprofen. It was concluded that acetaminophen was a potent analgesic that could be used to alleviate orthodontic treatment-related pain because its effect was at the level of the central nervous system and not at the cell level. The degree of the membrane as well as its inhibitory effect on OTM was not a matter of concern as it inhibited the PG synthesis only slightly. Ibuprofen, on the other hand, acted as a mild analgesic and, with its anti-inflammatory effect, also inhibited OTM. At the peripheral stage, ibuprofen reduces PGs, thereby influencing osteoclastic activity and the subsequent deceleration of orthodontic tooth movement. Instead of ibuprofen, acetaminophen is the recommended medication of choice for reliving pain and discomfort during orthodontic therapy.

Author (s) Details

Dr. A. Arif Yezdani
Department of Orthodontics and Dentofacial Orthopedics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India.

Dr. Mansi Giri
Department of Orthodontics and Dentofacial Orthopedics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India.

View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/287

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