News Release on Ulcer Research: September-2018

Does Spicy Food Really Cause Ulcers?

For decades, doctors thought ingestion plenty of spicy food caused abdomen ulcers, or painful sores on the liner of the passageway, abdomen or higher space of the tiny gut. It actually created sense, as patients would typically complain of burning abdomen pains when ingestion spicy food. The treatment: a strict diet of bland food (which didn’t really get eliminate the ulceration pain).

But within the Eighties, scientists place this recent wives’ tale to rest (at least within the health profession — plenty of individuals still believe this one). Studies showed that spicy food doesn’t cause ulcers, tho’ it will irritate existing ulcers, that explains the misunderstanding. [1]

A Case Report of Mucormycosis with Palatal Ulcer: A Rare Clinical Dilemma.

Mucormycosis represents a bunch of serious infections caused by fungi of the fungus order of taxon mucormycotina (formally referred to as the category zygomycetes). it’s extremely invasive and progressive malady leading to higher rates of morbidity and mortality. Newer therapies have declined the rates of mortality. Early initiation of medical care typically before confirmation of the diagnosing is critical to optimize outcomes. [2]

QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP AND MOLECULAR DOCKING STUDIES OF SOME SELECTED ANTI-ULCER INHIBITORS.

Proton pump inhibitors portray the primary alternative for treating varied ulceration diseases, as a result of they inhibit H+/K+-ATpase protein by covalently binding to an aminoalkanoic acid residue of either metal or nucleon pump. therefore, this protein could be a valid target for anti-ulcer medicine. A quantitative structure-activity relationship and molecular tying up studies are created on thirty benzos [d]thiazole series as H+/K+-ATPase inhibitors. Density practical Theory was accustomed optimized the pure mathematics of the anti-ulcer compounds. Four styles of molecular descriptors were generated in different to grasp the link that exit between anti-ulcer activity and structural properties of these compounds [3]

Challenges associated with the treatment of Buruli ulcer

Buruli ulceration (BU), caused by mycobacteria ulcerans (MU), is that the third most vital mycobacterial diseases when TB and Hansen’s disease in immunocompetent people. though the mode of transmission remains AN enigma, malady incidence has been powerfully connected to disturbed surroundings and wetlands. The blunt of the diseases is recorded in West African countries on the Gulf of Guinea, and kids fifteen years and below account for regarding forty-eighth of all cases globally. before 2004, wide surgical excisions and a surgical process of infected death tissues followed by skin attachment was the accepted definitive treatment of BU. [4]

Anti-ulcer Mechanisms of L-lysine in Male Wistar Rats

L-lysine is a necessary organic compound found in most supermolecule food sources, above all high-protein foods reminiscent of eggs, meat, soybean, milk, and fish. This organic compound has been reportable to own Associate in Nursing indirect inhibitor property. Antioxidants area unit best-known to own gastroprotective property. This study examined the result of L-lysine pre-treatment on Indocin elicited ulceration in male Wistar rats.

Fifty male Wistar rats were used for this study and were indiscriminately divided into 2 study teams of twenty 5 (25) animals every. the primary sub-group was used for the anti-ulcer studies; inhibitor enzymes (SOD, CAT, and MDA), gas, membrane bone cell count, and also the mean lesion score, whereas the second sub-group was used for the stomachic secretion study. every sub-group was divided into 5 teams with 5 animals per cluster namely: management, gastric antacid (20 mg/kg), L-lysine (100 mg/kg, two hundred mg/kg and four hundred mg/kg). [5]

Reference

[1] Does Spicy Food Really Cause Ulcers?

By Joseph Castro, Live Science Contributor, August 23, 2012, 02:00 am ET (web link)

[2] A Case Report of Mucormycosis with Palatal Ulcer: A Rare Clinical Dilemma.

Patel NR, Patel PA. A Case Report of Mucormycosis with Palatal Ulcer: A Rare Clinical Dilemma. Journal of the College of Physicians and Surgeons–Pakistan: JCPSP. 2018 Sep;28(9):721-3. (web link)

[3] QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP AND MOLECULAR DOCKING STUDIES OF SOME SELECTED ANTI-ULCER INHIBITORS.

baba Muhammad M, Uzairu A, Shallangwa GA, Uba S. QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP AND MOLECULAR DOCKING STUDIES OF SOME SELECTED ANTI-ULCER INHIBITORS. The Journal of Engineering and Exact Sciences. 2018 Aug 31;4(4):482. (web link)

[4] Challenges associated with the treatment of Buruli ulcer

Aboagye SY, Kpeli G, Tuffour J, Yeboah‐Manu D. Challenges associated with the treatment of Buruli ulcer. Journal of leukocyte biology. 2018 Aug 31. (web link)

[5] Anti-ulcer Mechanisms of L-lysine in Male Wistar Rats

Chukwu J. Okonkwo1, Francis S. Oluwole1* and Ayobami Dare2

1Department of Physiology, College of Medicine, University of Ibadan, Oyo State, Nigeria.

2Department of Physiology, College of Health Sciences, Bingham University, Karu, Nasarawa State, Nigeria. (web link)