Press Release on Antiretroviral Therapy: September-2018

Sustained benefit of early antiretroviral therapy

Antiretroviral medical care (ART) for HIV infection provides lasting protection against the sexual transmission of the virus from infected men and ladies to their HIV-uninfected sexual partners, investigators from the HIV bar Trials Network (HPTN) reported  nowadays at the eighth International AIDS Society (IAS) Conference on HIV pathologic process, Treatment and bar in Vancouver, Canada.

The study, called HPTN 052, began in 2005 and listed one,763 HIV serodiscordant couples — wherever one person is HIV-infected and therefore the alternative isn’t — at thirteen sites in 9 countries. the bulk of the couples were heterosexual (97%). HIV-infected partners were assigned to start out ART at the start of the study, referred to as the “early” arm, or later within the study, referred to as the “delayed” arm. Those on the delayed arm started ART once their bodies’ immune systems were declining. [1]

Survival in HIV-1 patients receiving antiretroviral therapy in Morocco

The purpose was to check factors related to the survival of HIV-1 patients receiving antiretroviral medical care in Morocco. This was a retrospective study of a cohort of one82 HIV-1 patients receiving antiretroviral medical care within the department of medicine venereology at the Military Instruction Hospital Mohamed V in capital of Morocco throughout the amount from one Jan 2006 to 1 Jan 2017. Death of any cause throughout the study amount was thought-about to be the results of HIV infection. The log-rank check was accustomed compare the survival curves supported determinants. [2]

How has the cost of antiretroviral therapy changed over the years? A database analysis in Italy

Background: the quantity of human immunological disorder virus (HIV)-related hospitalizations has bated worldwide in recent years, because of the provision of combined antiretroviral therapies (cART). the current analysis aimed to analyze the economic, and clinical burden of HIV management, once the introduction of the systematic use of cART.

Methods: information from HIV-infected patients, treated at Policlinico San Martino Hospital in Genova (Italy) were retrospectively collected. A comparison between the years 2009 and 2015 was performed. HIV-related admissions were known by victimization the Diagnosis-Related cluster (DRG) codes. [3]

Macrophages but not Astrocytes Harbor HIV DNA in the Brains of HIV-1-Infected Aviremic Individuals on Suppressive Antiretroviral Therapy

The question of whether or not the human brain is associate degree anatomical website of persistent HIV-1 infection throughout restrictive antiretroviral medical aid (ART) is important, however, remains nonreciprocal. The presence of the virus within the brains of HIV patients whose infectious agent load is effectively suppressed would demonstrate not solely the potential for the system to act as associate degree anatomical HIV reservoir, however, additionally, the imperative ought to perceive the factors contributory to persistent HIV behind the barrier. Here, we tend to investigate for the primary time the presence of cells harboring HIV polymer and RNA within the brains from subjects with undetectable plasma infectious agent load and sustained infectious agent suppression, as known by the National NeuroAIDS Tissue pool. [4]

Impact of Highly Active Antiretroviral Therapy on Hepatic Enzyme Elevation among HIV Seropositive Individuals: A Case-Control Study in Ghana

Background: Increasing access to extremely active antiretroviral medical care (HAART) in our population in recent times has necessitated the assessment of the impact of those therapies on internal organ enzymes. we tend to thus aim to assess the impact of extremely active antiretroviral medical care on internal organ catalysts and to determine the trend of internal organ enzyme elevation in HIV malady progression.

Method: 192 confirmed HIV people consisting of 104 medicine knowledgeable about and eighty-eight medicine naïve patients were recruited into the study. blood was taken for the assay of the base-forming enzyme (ALP), aminoalkanoic acid transferase (ALT), Aspartate transferase (AST) and Gamma-glutamyltransferase (GGT). [5]

Reference

[1] Sustained benefit of early antiretroviral therapy

Date: July 20, 2015, Source: FHI360 (web link)

[2] Survival in HIV-1 patients receiving antiretroviral therapy in Morocco

Titou H, Baba N, Kasouati J, Oumakir S, Frikh R, Boui M, Hjira N. Survival in HIV-1 patients receiving antiretroviral therapy in Morocco. Revue d’epidemiologie et de Sante Publique. 2018 Aug. (web link)

[3] How has the cost of antiretroviral therapy changed over the years? A database analysis in Italy

Taramasso L, Demma F, Bitonti R, Ferrazin A, Giannini B, Giacomini M, Beltramini S, Sasso E, Viscoli C, Di Biagio A. How has the cost of antiretroviral therapy changed over the years? A database analysis in Italy. BMC Health Services Research. 2018 Dec;18(1):691. (web link)

[4] Macrophages but not Astrocytes Harbor HIV DNA in the Brains of HIV-1-Infected Aviremic Individuals on Suppressive Antiretroviral Therapy

KoA, Kang G, Hattler JB, Galadima HI, Zhang J, Li Q, Kim WK. Macrophages but not Astrocytes Harbor HIV DNA in the Brains of HIV-1-Infected Aviremic Individuals on Suppressive Antiretroviral Therapy. Journal of Neuroimmune Pharmacology. 2018:1-0. (web link)

[5] Impact of Highly Active Antiretroviral Therapy on Hepatic Enzyme Elevation among HIV Seropositive Individuals: A Case-Control Study in Ghana

Louis Boafo Kwantwi1*, Christian Obirikorang1 and Margaret Agyei Frempong1

1Department of Molecular Medicine, School of Medical Sciences, Kwame Nkrumah University of Science  and Technology (KNUST), Kumasi, Ghana.

(web link)