A Comparative Cross-Sectional Study on Interplay of Adipokines in the Pathogenesis of Essential Hypertension in Ghana

A Comparative Cross-Sectional Study on Interplay of Adipokines in the Pathogenesis of Essential Hypertension in Ghana

Background: Mechanistic risk factors for hypertension are the renin-angiotensin-system (RAS), endothelial dysfunction and the sympathetic nervous system. The research sought to elucidate the interplay of adipokines in essential hypertension pathogenesis. Methodology: 200 confirmed hypertensive KATH patients and 50 age-matched normotensive patients were recruited in this comparative cross-sectional study. Blood pressure, anthropometric and socio-demographic data of the participants were obtained voluntarily. The participants’ serum levels of adiponectin, leptin and resistin were quantified using ELISA. It also analysed the renal function, lipid profile and glycemic status of all subjects. Results: A significantly higher anthropometric adiposity index was observed for hypertensive patients compared to normotensive patients, CI (p<0.0001), BAI (p<0.0001) and AVI (p=0.002). In hypertensive patients, adiponectin (p < 0.0001) levels were significantly lower than in normotensive patients. In addition, significantly higher serum leptin concentrations (p = 0.016) and leptinadiponectin ratio (p = 0.001) were observed in the hypertensive population compared to the normotensive group. In addition , the study found a direct association between serum leptin and weight (r = 0.111, p = 0.022), BMI (r = 0.129, p = 0.009) and WHtR (r = 0.098, p = 0.045), but an inverse relationship between hypertensive height (r = 0.134, p = 0.006). Serum leptin among hypertensive patients has a significant negative correlation with HDL-C (r = 0.174, p = 0.013). As predicted by resistin and adiponectin, the total aOR for hypertension was 1.12 (95% Cl, 1.02–1.25); p = 0.019) and 0.93 (95% Cl, 0.91–0.95); p = 0.0001) respectively. Conclusion: In the pathogenesis of essential hypertension, we found that elevations in serum levels of leptin and resistin and low levels of adiponectin may play a role. Therefore, as potential indicators for early and accurate detection of high blood pressure, adipokines may offer themselves. At the same time, the conclusions regarding the correlation between leptin and obesity are also confirmed by our current results. To investigate the physiological and pathological functions of adipokines in hypertension, further longitudinal studies in a larger population are warranted.

Author(s) Details

Dr. Osei Asibey
Department of Molecular Medicine, School of Medical Science, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana and Department of Clinical Biochemistry, Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana.

Francis Agyemang Yeboah
Department of Molecular Medicine, School of Medical Science, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.

W.
K. B. A. Owiredu
Department of Molecular Medicine, School of Medical Science, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.

Emmanuel Acheampong
Department of Molecular Medicine, School of Medical Science, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana and School of Medical and Health Sciences, Edith Cowan University, Western Australia, Australia.

Enoch Odame Anto
Department of Molecular Medicine, School of Medical Science, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana and School of Medical and Health Sciences, Edith Cowan University, Western Australia, Australia.

Isaac K. Owusu
Department of Medicine, Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana.

View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/313

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