An Overview: Far Eastern Scarlet-Like Fever is a Special Clinical and Epidemic Manifestation of Yersinia pseudotuberculosis Infection in Russia

An Overview: Far Eastern Scarlet-Like Fever is a Special Clinical and Epidemic Manifestation of Yersinia pseudotuberculosis Infection in Russia

In various countries of the world, pseudotuberculosis was found in humans until the 1950s as a rare sporadic disease that appeared in the form of acute appendicitis and mesenteric lymphadenitis. The Yersinia pseudotuberculosis (Y. pseudotuberculosis) infection also triggers disease outbreaks with extreme systemic inflammatory symptoms in Russia and Japan, and this form of the disease has been known as Far Eastern Scarlet-like Fever since 1959 (FESLF). Russian researchers have shown that a particular clonal line of Y is associated with the FESLF pathogen. Via pseudotuberculosis, Relevant plasmid profile (pVM82, pYV 48 MDa), sequence (2ST) and allele of the yadA gene (1st allele). The discovery in people abroad of the first cases of pseudotuberculosis was the result of random discoveries of lethal septic diseases diagnosed on the basis of a sectional substance bacteriological analysis. The most important advances in the FESLF research since its discovery in the Far East have been summarised by this analysis. The FESLF causative agent has been shown to be distinguished by a peculiar psychrophilicity phenomenon, consisting of its ability to replicate in the atmosphere with its biologically low and variable temperature (4-12 ° C) at which the pathogen multiplies and accumulates while retaining or growing its virulence, ensuring the disease phase emerges and grows. Y.’s primary genetic and biochemical pathways. It was characterised by pseudotuberculosis adaptation to changing environmental conditions, and the morphological manifestations of the adaptive heterogeneity of these bacteria in different conditions of their environment were exposed. The primary characteristics of FESLF pathogenesis and morphogenesis, including those associated with Y. Toxigenicity of pseudotuberculosis, submitted. The pathogenetic importance of the PVM82 plasmid, found only in the pathogen of the FESLF, was shown. The importance of further research on the FESLF issue has recently been linked with the study of dormant forms of Y. Pseudotuberculosis and the concept of chronic infection as pseudotuberculosis.

Author(s) Details

Larisa M. Somova
Somov Research Institute of Epidemiology and Microbiology, Ministry of Science and Higher Education, 690087 Vladivostok, Russia.

Fedor F. Antonenko
Russian Scientific Center for Roentgen-Radiology, Ministry of Health, 117997 Moscow, Russia.

Nelly F. Timchenko
Somov Research Institute of Epidemiology and Microbiology, Ministry of Science and Higher Education, 690087 Vladivostok, Russia.

Irina N. Lyapun
Somov Research Institute of Epidemiology and Microbiology, Ministry of Science and Higher Education, 690087 Vladivostok, Russia.

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