Annona stenophylla, a Medicinal Herb with Potential for Treating Sugar Imbalances in Diabetes Mellitus

Annona stenophylla, a Medicinal Herb with Potential for Treating Sugar Imbalances in Diabetes Mellitus

Diabetes mellitus (DM) is a chronic metabolic condition characterised by insulin secretion that is defective. The disease poses a significant health risk to healthcare systems around the world. Blindness, kidney failure, neuropathy, amputations, cardiovascular disease and stroke may be caused by complications. By 2030, 600 million people will be infected globally and will need around USD 2.3 trillion to tackle the disease (WHO). It is estimated that the world drug market for antidiabetic drugs is USD68bln, mainly insulin and oral hypoglycaemics. With China and India having officially registered a variety of antidiabetic herbal medicines, several traditional medicinal herbs are still in use. Antidiabetic herbal medicines may complement or may have a benefit over modern medicines, as they often heal through different mechanisms and may often be cheaper. The prevalence of diabetes in Zimbabwe is estimated at 10% of the population and is frequently associated with obesity and HIV/AIDS with hypertension (30% prevalence) (13 percent ). Diabetes is an underlying disease of aggravated COVID-19 illness worldwide. Annona stenopylla (Annonaceae) is an indigenous shrub used in herbal medicine as a food plant and to treat a variety of ailments that have also shown hypoglycaemic effects and may be used to relieve some of the underlying conditions observed in patients with COVID-19 and survivors of coronavirus. From Samples of A. Stenophylla was found to contain fatty acids, proteins and mineral elements of secondary metabolites, carbohydrates; to have antimicrobial, analgesic, antioxidant, antidiarrhoeal and dyslipidemic properties; Having hypoglycaemic and antidiabetic properties in laboratory animals and having several modes of action and being relatively healthy in acute toxicity studies. A. Stenophylla is widely distributed in Zimbabwe and can be sustainably propagated and cultivated. The production of herbal medicines and polyherbal formulations could allow lower doses to be used in the treatment of DM and, in particular, in combination with modern medicines.

Author(s) Details

Tafadzwa Taderera
School of Pharmacy, College of Health Sciences, University of Zimbabwe, P.O.Box MP 167, Mount Pleasant, Harare, Zimbabwe.

Lameck Shoriwa Chagonda
School of Pharmacy, College of Health Sciences, University of Zimbabwe, P.O.Box MP 167, Mount Pleasant, Harare, Zimbabwe.

Exnevia Gomo
Department of Medical Laboratory Sciences, University of Zimbabwe, P.O.Box A178, Avondale Harare, Zimbabwe.

David Katerere
Department of Biomedical Sciences, Tshwane University of Technology, Private Bag X680, Pretoria 0001, South Africa.

Leshweni J. Shai
Department of Biomedical Sciences, Tshwane University of Technology, Private Bag X680, Pretoria 0001, South Africa.

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