Mullerian Adenosarcoma of Uterus Following Tamoxifen Use- A Case Report

Mullerian Adenosarcoma of Uterus Following Tamoxifen Use- A Case Report

A unusual tumor is mullerian adenosarcoma. To date, about 200 cases have been identified. In peri- or postmenopausal women, this tumor typically occurs and asymptomatic presentation is rarely recorded. A risk factor for this tumor development has been considered to be the use of tamoxifen. A woman who was referred for the identification of a suspected malignant mass on a PET scan is mentioned here, which was performed to follow up the patient during breast cancer treatment. The patient had a history of 5 years of tamoxifen use. She was asymptomatic, however. Total abdominal hysterectomy was performed with bilateral salphingoo-ophoectomy. The diagnosis of mullerian adenosarcoma was confirmed by a histological examination. There was an uneventful post-operative course and radiotherapy was later performed at a nuclear medicine facility. This article would like to highlight the importance for both gynecologists and pathologists of identifying this tumor. Depending on the sarcomatous portion, lympho-invasion, and myoinvasion, uterine adenosarcoma has a variable survival rate. No lymph invasion and no myoinvasion were shown by this patient, which accounts for her good prognosis. As a strong association has been shown in documented cases, oncologists and gynecologists should be mindful that this tumor may occur in patients with a history of tamoxifen use.

Author (s) Details

Dr. Himleena Gautam
Department of Obstetrics & Gynaecology, Apollo Hospitals, Guwahati, Assam, India.

Dr. K. K. Kathar
Department of Obstetrics & Gynaecology, Apollo Hospitals, Guwahati, Assam, India.

Dr. Papari Goswami
Department of Pathology, Apollo Hospitals, Guwahati, Assam, India.

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