Neurotropic Action of the Hydroalcoholic Extract of Melissa officinalis in the Mouse

A preserved hydroalcoholic extract of beebalm L. (Lamiaceae) has been evaluated for behavioural effects in mice. in step with the normal use of M. officinalis, sedative properties are confirmed for low doses by the decrease of behavioural parameters measured during a non-familiar surroundings check (staircase check) and during a acquainted surroundings test (two compartment test). With high doses, a peripheral analgesic activity was obtained by reducing the carboxylic acid acid-induced pain (writhing test); what is more, the plant extract evoked the sleep in mice once treatment with associate degree infrahypnotic dose of Nembutal and potentialised the sleep evoked by a hypnotic dose of Nembutal. [1]

Fulminant hepatitis during self-medication with hydroalcoholic extract of green tea

Despite associate ancient name for potential phytotherapeutic effects and innocuity, ancient flavoring drugs has antecedently been involved in severe adverse events. Exolise is associate eightieth ethanolic dry extract of tea leaf (Camellia sinensis) standardized at twenty fifth catechins expressed as epigallocatechin gallate, containing 5–10% alkaloid. it’s been offered in France, Belgium, Spain and also the uk since 1999, as associate adjuvant medical aid to be used in weight loss programmes. In numerous studies, tea leaf must date been thought of helpful for its potential viscus protecting properties. during this study, we tend to report a case of sudden liver disease throughout self-medication with Exolise, requiring liver transplantation. [2]

Oral anti-inflammatory and anti-ulcerogenic activities of a hydroalcoholic extract and partitioned fractions of Turnera ulmifolia (Turneraceae)

Anti-inflammatory studies were conducted on rats or mice employing a crude hydroalcoholic extract of the aerial components of Turnera ulmifolia and it’s partitioned off fractions, i.e. the liquid, ester and ethanolic fractions. The hydroalcoholic extract and it’s fractions (aqueous and ethanolic) restrained carrageenan-induced dropsy. However, solely the ethanolic fraction was employed in the opposite experiments because of it’s yield. The extract conjointly restrained the cotton pellet tumor and also the increase of vascular  porosity elicited by amine, monoamine neurotransmitter and autocoid E2, however not that made by bradykinin. The extract or the fraction didn’t gift analgesic activity within the wriggling take a look at victimization carboxylic acid and didn’t cut back croton oil-induced ear dropsy in mice. [3]

Effect of Vitis vinifera hydroalcoholic extract against oxaliplatin neurotoxicity: in vitro and in vivo evidence

Oxaliplatin treatment is related to the event of a dose-limiting painful pathology impairing patient’s quality of life. Since aerophilic unbalance could be a relevant mechanism of oxaliplatin neurotoxicity, we have a tendency to assessed the potential inhibitor properties of grapevine extract in reducing oxaliplatin-induced pathology as a valuable therapeutic chance. A hydroalcoholic extract of grapevine red leaf was characterised and tested in primary rat glial cell cells treated with oxaliplatin (100 μM). Oxaliplatin morbidness within the human glandular carcinoma cell line HT-29 was evaluated in the absence and presence of the extract. In vivo, pain hypersensitivity was measured in a very rat model of pathology induced  by oxaliplatin and ex vivo molecular targets of chemical reaction balance were studied. [4]

The Effect of Hydroalcoholic Extract of Ferulago angulata on Liver Function Parameters and Antioxidant Status in Alloxan-Induced Diabetic Rats

Aim: The aim of this study was to judge the hepatoprotective and inhibitor activities of Ferulago angulata Extract (FAE) in experimental diabetic rats.

Materials and Methods: fifty four male person Wistar rats divided into half dozen teams (n=9). polygenic disease was induced  altogether animals except those in cluster one by the daily intraperitoneal injection of one hundred twenty mg/kg alloxan hydrate for three consecutive days. Experimental diabetic rats in teams 3-5 were orally administered with explosive device (200,400, and 800 mg/kg/day, respectively). cluster half dozen was treated with a hundred and fifty mg/kg of antidiabetic drug. At the tip of week four, the rats were anesthetised and so sacrificed by internal organ puncture. Then, the degree of liver markers, malondialdehyde (MDA), and inhibitor enzymes capability were evaluated in every cluster. [5]

Reference

[1] Soulimani, R., Fleurentin, J., Mortier, F., Misslin, R., Derrieu, G. and Pelt, J.M., 1991. Neurotropic action of the hydroalcoholic extract of Melissa officinalis in the mouse. Planta Medica, 57(02), (Web Link)

[2] Gloro, R., Hourmand-Ollivier, I., Mosquet, B., Mosquet, L., Rousselot, P., Salamé, E., Piquet, M.A. and Dao, T., 2005. Fulminant hepatitis during self-medication with hydroalcoholic extract of green tea. European journal of gastroenterology & hepatology, 17(10), (Web Link)

[3] Antonio, M.A. and Brito, A.S., 1998. Oral anti-inflammatory and anti-ulcerogenic activities of a hydroalcoholic extract and partitioned fractions of Turnera ulmifolia (Turneraceae). Journal of ethnopharmacology, 61(3), (Web Link)

[4] Effect of Vitis vinifera hydroalcoholic extract against oxaliplatin neurotoxicity: in vitro and in vivo evidence
Laura Micheli, Luisa Mattoli, Anna Maidecchi, Alessandra Pacini, Carla Ghelardini & Lorenzo Di Cesare Mannelli
Scientific Reports volume 8, Article number: 14364 (2018) (Web Link)

[5] Mousavi-Ezmareh, S.-F., Mazani, M., Heidarian, E., Moghadam, R. A., Rafieian-kopaei, M., Mardanian, G., Rezagholizadeh, L. and Shamsazar, A. (2017) “The Effect of Hydroalcoholic Extract of Ferulago angulata on Liver Function Parameters and Antioxidant Status in Alloxan-Induced Diabetic Rats”, European Journal of Medicinal Plants, 20(2), (Web Link)

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