In oncology practise, metastatic bone disease is a common concern. Bone is a common location of metastasis in solid malignancies. After the liver and the lungs, bones are the third most common site of metastases in advanced cancer. Breast, lung, and prostate cancers, as well as urinary bladder, uterine, kidney, melanoma, and thyroid cancers, are the most prevalent primary sites for bone metastases. In skeletal metastases, multiple metastases are common, with solitary metastases occurring in only 10% of cases. Pain is caused by bone metastases in two ways: directly by local invasion and indirectly by changes in the remodelling activity of osteoblasts and osteoclasts. The most effective treatment for bone metastases is radiotherapy. Patients getting palliative radiation frequently have pain flare-ups. Dexamethasone is a long-acting steroid that has been found to help reduce pain flare-ups. The study’s main goal is to see if dexamethasone can help reduce pain flare-ups after radiation for severe bone metastases.

Author(S) Details

Sunder Singh
Department of Radiation Oncology, Pt. BD Sharma PGIMS, Rohtak Haryana, India.

Rakesh Dhankhar
Department of Radiation Oncology, Pt. BD Sharma PGIMS, Rohtak Haryana, India.

Kiran Dahiya
Department of Biochemistry, Pt. BD Sharma PGIMS, Rohtak, Haryana, India.

View Book:- https://stm.bookpi.org/RDMMR-V16/article/view/5244

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