Ischemia Modified Albumin and Type 2 Diabetes Mellitus

Ischemia Modified Albumin and Type 2 Diabetes Mellitus

Human serum albumin is the circulating protein which is synthesized in liver. It undergoes various

modifications in its properties in type II diabetic patients. There is alteration in N-terminal which leads

to its reduced binding to other metals and is known as Ischemia Modified Albumin which can be

measured by the albumin cobalt binding assay which is based on the fact that IMA has reduced

capacity to bind cobalt as compared to Albumin. IMA is a proven marker for cardiovascular diseases.

It produces reactive oxygen species and is also a common risk factor for cardiovascular events.

Measuring its levels in type II Diabetes Mellitus may help to predict the status of complications

associated with it.

Author (s) Details

Deepika Dalal

Department of Biochemistry, Pt. BD Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India.

Kiran Dahiya

Department of Biochemistry, Pt. BD Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India.

Keerti Gupta

Department of Biochemistry, Pt. BD Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India.

View Book :-https://bp.bookpi.org/index.php/bpi/catalog/book/248

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