Non-steroidal anti-inflammatory drugs (NSAIDs) are considered as the best treatment for conditions associated with pain, fever and inflammation. Non-steroidal anti-inflammatory drugs exert their therapeutic effects by blocking prostaglandin synthesis from arachidonic acid, which inhibits the activity of cyclooxygenases (COX-1 and COX-2). COX-1 is located in the stomach, kidney and other tissues, while COX-2 is located at inflammation sites. One of the disadvantages of the NSAIDs is their bitter sensation. This chapter discusses a novel approach to be used in the design of active sites of bitter taste receptors, especially TAS2R14, by using the X-ray crystal structure of the enzyme COX-2 and chemical structures of commonly used non-steroidal anti-inflammatory drugs (NSAIDs) that bind effectively to COX enzymes and activate the bitter taste receptor TAS2R14. The suggested approach consists of docking calculations of the NSAIDs (ligands) to the active site of COX-2 and utilizing the data obtained in better understanding the nature of the interactions between bitter tastants and the chemical groups within the active site of TAS2R14 receptor.
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