Latest News on Herbal Formulation : March – 2020

Latest News on Herbal Formulation : March – 2020

Protective effect of HD-03, a herbal formulation, against various hepatotoxic agents in rats

HD-03 is a polyherbal formulation containing plant drugs which are known for their hepatoprotective properties in the Ayurvedic system of medicine. In the present study, the formulation was evaluated for its protective effect against diverse hepatotoxic agents viz., paracetamol, thioacetamide and isoniazid. [1]

Effect of Trasina, an Ayurvedic herbal formulation, on pancreatic islet superoxide dismutase activity in hyperglycaemic rats.

Diabetes mellitus was induced in male CF strain rats by streptozotocin (STZ) and hyperglycaemia and superoxide dismutase (SOD) activity of pancreatic islet cells was assessed on days 7, 14, 21 and 28. STZ induced significant hyperglycaemia and a concomitant decrease in islet cell SOD activity. [2]

Anti-ulcer and antioxidant activity of DHC-1, a herbal formulation

DHC-1, a herbal formulation, was tested for its anti-ulcer and antioxidant activity in rats. Effect of various doses (125, 250, 500, and 1000 mg/kg, p.o.) of DHC-1 was studied on gastric secretion and gastric ulcers in pylorus-ligation and on ethanol-induced gastric mucosal injury in rats. [3]

Effect of Ciklavit® – a Nigerian Poly-herbal Formulation on the Dissolution Profile of Proguanil Tablets: Potential for Herb-drug Interaction

Aim: Herb-drug interaction is a growing concern due to the increasing consumption of herbal medicines among populations globally. Assessment of potential interaction of herbs with concomitantly administered drugs is thus very necessary to ensure patient safety. The aim of this study was to determine the effect of Ciklavit® on the in vitro release profile of proguanil tablets as indicator of potential in vivo herb-drug interaction. [4]

Physico-Chemical Evaluation of Guduchyadi Kwatha for Instant Use: An Ayurvedic Herbal Formulation

Introduction: Kwatha (decoction) preparations are one among commonest practiced Ayurvedic dosage forms, which are highly effective, but they are to be used when freshly prepared due to short shelf life (i.e. 1/2- 1 day), and they are often overlooked due to the preparation method and palatability. [5]

Reference

[1] Mitra, S.K., Venkataranganna, M.V., Sundaram, R. and Gopumadhavan, S., 1998. Protective effect of HD-03, a herbal formulation, against various hepatotoxic agents in rats. Journal of Ethnopharmacology63(3), pp.181-186.

[2] Bhattacharya, S.K., Satyan, K.S. and Chakrabarti, A., 1997. Effect of Trasina, an Ayurvedic herbal formulation, on pancreatic islet superoxide dismutase activity in hyperglycaemic rats. Indian journal of experimental biology35(3), pp.297-299.

[3] Bafna, P.A. and Balaraman, R., 2004. Anti-ulcer and antioxidant activity of DHC-1, a herbal formulation. Journal of Ethnopharmacology, 90(1), pp.123-127.

[4]Akinleye, M. O., Amaeze, O. U., Opeodu, O. T. and Okubanjo, O. O. (2016) “Effect of Ciklavit® – a Nigerian Poly-herbal Formulation on the Dissolution Profile of Proguanil Tablets: Potential for Herb-drug Interaction”, Journal of Pharmaceutical Research International, 12(6), pp. 1-9. doi: 10.9734/BJPR/2016/28298.

[5] Prajapat, R., Sharma, R. and Prajapati, P. K. (2014) “Physico-Chemical Evaluation of Guduchyadi Kwatha for Instant Use: An Ayurvedic Herbal Formulation”, Journal of Pharmaceutical Research International, 4(22), pp. 2599-2613. doi: 10.9734/BJPR/2014/12978.

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