Anti-carcinogenic Effects of the Flavonoid Luteolin

Luteolin may be a flavonoid that is a component of our daily nutrition in comparatively low amounts (less than one mg/day). withal, some medical specialty studies counsel AN inverse correlation between luteolin intake and also the risk of some cancer sorts. Luteolin displays specific medication and anti-carcinogenic effects, which might solely partially be explained by its anti-oxidant and radical scavenging capacities. Luteolin will delay or block the event of cancer cells in vitro and in vivo by protection from cancer stimuli, by inhibition of growth cell proliferation, by induction of cell cycle arrest and by induction of necrobiosis via intrinsic and extraneous signal pathways. in comparison to alternative flavonoids, luteolin was typically among the foremost effective ones, inhibiting growth cell proliferation with IC50 values between three and fifty μM in vitro and in vivo by five to ten mg/kg i.p., intragastric application of zero.1–0.3 mg/kg/d, or as artificial additive in concentrations of fifty to two hundred ppm. [1]

Intestinal absorption of luteolin and luteolin 7‐O‐β‐glucoside in rats and humans

In this study, we tend to investigated the enteric absorption of luteolin and luteolin 7‐O‐β‐glucoside in rats by HPLC. The absorption analysis victimisation rat everted intestine incontestible that luteolin was regenerate to glucuronides throughout passing through the enteric tissue layer which luteolin 7‐O‐β‐glucoside was absorbed once chemical reaction to luteolin. Free luteolin, its conjugates and alkyl group conjugates were gift in rat plasma once dosing. this means that some luteolin will escape the enteric conjugation and also the internal organ sulfation/methylation. LC/MS analysis showed that the most conjugate that circulates within the blood was a monoglucuronide of the unchanged aglycone. Luteolin in propyleneglycol was absorbed earlier than that in zero.5% cellulose. The plasma concentration of luteolin and its conjugates reached the best level fifteen min and thirty min once dosing with luteolin in propyleneglycol, severally. [2]

Distribution and Biological Activities of the Flavonoid Luteolin

Epidemiological proof suggests that flavonoids might play a crucial role within the cut risk of chronic diseases related to a diet wealthy in plant-derived foods. Flavonoids also are common constituents of plants utilized in ancient medication to treat a good vary of diseases. the aim of this text is to summarize the distribution and biological activities of 1 of the foremost common flavonoids: luteolin. This flavonoid and its glycosides are cosmopolitan within the plant kingdom; they’re gift in several plant families and are known in division, division Pteridophyta, Pinophyta and Angiospermae. Dietary sources of luteolin embody, as an example, carrots, peppers, celery, olive oil, peppermint, thyme, rosemary and oregano. diagnosing studies have shown that this flavone possesses a spread of medical specialty activities, as well as inhibitor, medication, antimicrobial and malignant tumor activities. [3]

Decrease of AIM2 mediated by luteolin contributes to non-small cell lung cancer treatment

Non-small cell carcinoma (NSCLC) is one in all the foremost common malignancies within the world. though in depth studies showed that luteolin exhibited anticancer effects against NSCLC, the mechanism has not been absolutely established. within the gift study, we tend to found that luteolin considerably reduced the expression of absent in malignant melanoma a pair of (AIM2) at each messenger RNA and macromolecule levels resulting in the suppression of AIM2 inflammasome activation, that iatrogenic G2/M section arrest and suppressed epithelial–mesenchymal transition (EMT) in NSCLC. what is more, the restrictive effects of luteolin on NSCLC cells were abolished by the knockdown of AIM2. [4]

Antioxidant Activity of Polyphenolic Leaf Extract from Santolina chamaecyparissus L. (Asteraceae) and the Isolated Luteolin-7-O-Glucoside

Aim: this study aimed to research the chemical constituents and inhibitor potential of bush polyphenolic extract (SCPE).

Materials and Methods: The extract containing phenoplast compounds, was extracted with ester and luteolin-7-O-glucoside was separated and sublimate exploitation flash action on colloid column. This isolated compound was known in step with its chemistry properties and spectral knowledge (UV, LC–TOF-MS, 1H NMR, 13C proton magnetic resonance and second NMR). In vitro inhibitor activity of the isolated compound and SCPE was investigated exploitation DPPH•, ABTS+, reducing power, superoxide radical scavenging and β-carotene bleaching assays.

Results: Results showed that SCPE and luteolin-7-O-glucoside exhibited important inhibitor activity. The inhibitor activity of SCPE was akin to that of luteolin-7-O-glucoside. Luteolin-7-O-glucoside was isolated for the primary time from bush polyphenolic extract. [5]

Reference

[1] Seelinger, G., Merfort, I., Wölfle, U. and Schempp, C.M., 2008. Anti-carcinogenic effects of the flavonoid luteolin. Molecules, 13(10), (Web Link)

[2] Shimoi, K., Okada, H., Furugori, M., Goda, T., Takase, S., Suzuki, M., Hara, Y., Yamamoto, H. and Kinae, N., 1998. Intestinal absorption of luteolin and luteolin 7‐O‐β‐glucoside in rats and humans. FEBS letters, 438(3), (Web Link)

[3] López-Lázaro, M., 2009. Distribution and biological activities of the flavonoid luteolin. Mini reviews in medicinal chemistry, 9(1), (Web Link)

[4] Decrease of AIM2 mediated by luteolin contributes to non-small cell lung cancer treatment
Qian Yu, Minda Zhang, Qidi Ying, Xin Xie, Shuwen Yue, Bending Tong, Qing Wei, Zhaoshi Bai & Lingman Ma
Cell Death & Disease volume 10, Article number: 218 (2019) (Web Link)

[5] Boudoukha, C., Bouriche, H., Elmastas, M., Aksit, H., Kayir, O., Genc, N. and Senator, A. (2018) “Antioxidant Activity of Polyphenolic Leaf Extract from Santolina chamaecyparissus L. (Asteraceae) and the Isolated Luteolin-7-O-Glucoside”, Journal of Pharmaceutical Research International, 22(3), (Web Link)

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