Latest Research on Levothyroxine : March – 2020

Levothyroxine Treatment in Euthyroid Pregnant Women with Autoimmune Thyroid Disease: Effects on Obstetrical Complications

Context: Euthyroid women with autoimmune thyroid disease show impairment of thyroid function during gestation and seem to suffer from a higher rate of obstetrical complications.

Objective: We sought to determine whether these women suffer from a higher rate of obstetrical complications and whether levothyroxine (LT4) treatment exerts beneficial effects. [1]

Suppressive Therapy with Levothyroxine for Solitary Thyroid Nodules

Thyroid nodules are present in up to 50 percent of adults in the fifth decade of life. Patients are often treated with thyroxine in order to reduce the size of the nodule, but the efficacy of thyrotropin-suppressive therapy with thyroxine remains uncertain. [2]

Effect of Calcium Carbonate on the Absorption of Levothyroxine

Context The effect of calcium carbonate on the absorption of levothyroxine has not been studied systematically. Such a potential drug interaction merits investigation because concurrent treatment with both drugs is common, particularly in postmenopausal women. [3]

Timing of Levothyroxine in the Treatment of Primary Hypothyroidism

Aim: Timing of levothyroxine (L-thyroxine) administration seems beneficial for early obtaining thyroid state. The present study aimed at investigating the best time of L-thyroxine administration that can achieve earlier normalization of thyroid stimulating hormone (TSH) and free thyroxine (FT4) levels in patients with primary hypothyroidism [4]

Factor Affecting Photo and Thermal Stability of Levothyroxine Sodium

The aim of this works is to study the thermal and photo-decomposition of levothyroxine sodium.The effect of light on the stability of the drug in solution was studied under conditions of several parameters (concentration and pH). Photo-decomposition was carried out by exposing the drug to direct sunlight, while thermal decomposition was carried out by heating the drug at different temperatures. [5]


[1] Negro, R., Formoso, G., Mangieri, T., Pezzarossa, A., Dazzi, D. and Hassan, H., 2006. Levothyroxine treatment in euthyroid pregnant women with autoimmune thyroid disease: effects on obstetrical complications. The Journal of Clinical Endocrinology & Metabolism91(7), pp.2587-2591.

[2] Gharib, H., James, E.M., Charboneau, J.W., Naessens, J.M., Offord, K.P. and Gorman, C.A., 1987. Suppressive therapy with levothyroxine for solitary thyroid nodules. New England Journal of Medicine317(2), pp.70-75.

[3] Singh, N., Singh, P.N. and Hershman, J.M., 2000. Effect of calcium carbonate on the absorption of levothyroxine. Jama283(21), pp.2822-2825.

[4] Ahmed, J.H., AL-Emara, Z.N.A.N. and Mansour, A.A., 2016. Timing of Levothyroxine in the Treatment of Primary Hypothyroidism. Journal of Advances in Medicine and Medical Research, pp.1-6.

[5] Abdallah, S. and Mohamed, I., 2016. Factor affecting photo and thermal stability of levothyroxine sodium. Journal of Pharmaceutical Research International, pp.1-11.