News Update on Anticancer: March – 2020

Polymer conjugates as anticancer nanomedicines

The transfer of polymer–protein conjugates into routine clinical use, and the clinical development of polymer–anticancer-drug conjugates, both as single agents and as components of combination therapy, is establishing polymer therapeutics as one of the first classes of anticancer nanomedicines. [1]

Anticancer activities of histone deacetylase inhibitors

Histone deacetylases (HDACs) are enzymes involved in the remodelling of chromatin, and have a key role in the epigenetic regulation of gene expression. In addition, the activity of non-histone proteins can be regulated through HDAC-mediated hypo-acetylation. In recent years, inhibition of HDACs has emerged as a potential strategy to reverse aberrant epigenetic changes associated with cancer, and several classes of HDAC inhibitors have been found to have potent and specific anticancer activities in preclinical studies. [2]

Flavonoids: Promising anticancer agents

Flavonoids are polyphenolic compounds that are ubiquitously in plants. They have been shown to possess a variety of biological activities at nontoxic concentrations in organisms. The role of dietary flavonoids in cancer prevention is widely discussed. Compelling data from laboratory studies, epidemiological investigations, and human clinical trials indicate that flavonoids have important effects on cancer chemoprevention and chemotherapy.  [3]

Phytochemical Studies and Evaluation of Antioxidant, Anticancer and Antimicrobial Properties of Conocarpus erectus L. Growing in Taif, Saudi Arabia

The use of plants and their derived substances increases day by day for the discovery of new therapeutic agents owing to their versatile applications. Conocarpus erectus L. (family Combretaceae) is one of two species in the genus Conocarpus widely spread in Taif and other parts of the Kingdom of Saudi Arabia. It is used in some countries as folk remedy for anemia, catarrh, conjunctivitis, diabetes, diarrhea and fever. To our knowledge from literatures there is little work about phytochemical contents and biological activities of C. erectus which encouraged the authors to carry out this study. [4]

Anticancer Activity of Three Jamaican Macroalgae against Prostate, Pancreatic and Skin Cancers

Aims: Cancer is one of the leading chronic diseases that may lead to death. The search for new therapeutic, medicinal and nutraceutical compounds from folkloric plants including the marine flora are globally important objectives. Therefore the biological assessment of macroalgae is critical. Methodology: Three macroalgae, Galaxaura oblongata, Dictyota cervicornis and Halimeda incrassata were collected from the southern coast of Jamaica and assessed for their anticancer activity against prostate, pancreatic and skin (melanoma) cancers using PC-3, MiaPaca-2 and A375 cell lines respectively. The crude hexane, ethyl acetate and methanol extracts were prepared and bio-assayed using the WST-1 cell proliferation assay. Results: The results indicated that the crude ethyl acetate extract for three of the macroalgae ; [5]



[1] Duncan, R., 2006. Polymer conjugates as anticancer nanomedicines. Nature reviews cancer6(9), pp.688-701.

[2] Bolden, J.E., Peart, M.J. and Johnstone, R.W., 2006. Anticancer activities of histone deacetylase inhibitors. Nature reviews Drug discovery5(9), pp.769-784.

[3]Ren, W., Qiao, Z., Wang, H., Zhu, L. and Zhang, L., 2003. Flavonoids: promising anticancer agents. Medicinal research reviews23(4), pp.519-534.

[4] Abdel-Hameed, E.S.S., Bazaid, S.A., Shohayeb, M.M., El-Sayed, M.M. and El-Wakil, E.A., 2012. Phytochemical studies and evaluation of antioxidant, anticancer and antimicrobial properties of Conocarpus erectus L. growing in Taif, Saudi Arabia. European Journal of Medicinal Plants, pp.93-112.

[5] Lowe, H.I., Daley, D., Watson, C., Powell, S.A., Ayeah, K.N., Toyang, N.J., Bryant, J. and Lamm, A.S., 2016. Anticancer Activity of Three Jamaican Macroalgae against Prostate, Pancreatic and Skin Cancers. European Journal of Medicinal Plants, pp.1-5.