Latest Research News on Saccharomyces Cerevisiae: Jan – 2020

Transcriptional Regulatory Networks in Saccharomyces cerevisiae

We have determined how most of the transcriptional regulators encoded within the eukaryote Saccharomyces cerevisiaeassociate with genes across the genome in living cells. even as maps of metabolic networks describe the potential pathways which will be employed by a cell to accomplish metabolic processes, this network of regulator-gene interactions describes potential pathways yeast cells can use to manage global organic phenomenon programs. We use this information to spot network motifs, the only units of specification, and demonstrate that an automatic process can use motifs to assemble a transcriptional regulatory network structure. Our results reveal that eukaryotic cellular functions are highly connected through networks of transcriptional regulators that regulate other transcriptional regulators. [1]

The proteome of Saccharomyces cerevisiae mitochondria

We performed a comprehensive approach to work out the proteome of baker’s yeast mitochondria. The proteins of highly pure yeast mitochondria were separated by several independent methods and analyzed by tandem MS. From >20 million MS spectra, 750 different proteins were identified, indicating an involvement of mitochondria in numerous cellular processes. All known components of the organic process machinery, the tricarboxylic acid cycle, and therefore the stable mitochondria-encoded proteins were found. supported the mitochondrial proteins described within the literature thus far, we calculate that the identified proteins represent ≈90% of all mitochondrial proteins. The function of 1 / 4 of the identified proteins is unknown. The mitochondrial proteome will provide a crucial database for the analysis of latest mitochondrial and mitochondria-associated functions and therefore the characterization of mitochondrial diseases. [2]

Genetic and physical maps of Saccharomyces cerevisiae

Genetic and physical maps for the 16 chromosomes of baker’s yeast are presented. The arrangement is that the results of 40 years of genetic analysis. The physical map was produced from the results of a world systematic sequencing effort. [3]

Fermentation innovation through complex hybridization of wild and domesticated yeasts

The most common fermented beverage, lager, is produced by interspecies hybrids of the brewing yeast baker’s yeast and its wild relative S. eubayanus. Lager-brewing yeasts aren’t the sole example of hybrid vigour or heterosis in yeasts, but the complete breadth of interspecies hybrids related to human fermentations has received less attention. Here we present a comprehensive genomic analysis of 122 Saccharomyces hybrids and introgressed strains. These strains arose from hybridization events between two to four species. Hybrids with S. cerevisiae contributions originated from three lineages of domesticated S. cerevisiae, including the main wine-making lineage and two distinct brewing lineages. [4]

In silico Phylogenetics and Molecular Docking Studies of Rhodanese from Yeast (Saccharomyces cerevisiae)

Aim: to guage the in silico phylogenetics, separation energy and poses of rhodanese from Yeast (Saccharomyces cerevisiae) with known substrates and inhibitors.

Study Design: The three categories of ligands which include substrates, salts and effectors, were used against the phylogenetically conserved rhodanese from yeast.

Place and Duration of Study: The study was administered at the Enzyme Biotechnology and Bioinformatics Unit, Department of Biochemistry, Federal University of Technology Akure, Nigeria. The research was administered from January to March 2018. [5]

Reference

[1] Lee, T.I., Rinaldi, N.J., Robert, F., Odom, D.T., Bar-Joseph, Z., Gerber, G.K., Hannett, N.M., Harbison, C.T., Thompson, C.M., Simon, I. and Zeitlinger, J., 2002. Transcriptional regulatory networks in Saccharomyces cerevisiae. science, 298(5594), (Web Link)

[2] Sickmann, A., Reinders, J., Wagner, Y., Joppich, C., Zahedi, R., Meyer, H.E., Schönfisch, B., Perschil, I., Chacinska, A., Guiard, B. and Rehling, P., 2003. The proteome of Saccharomyces cerevisiae mitochondria. Proceedings of the National Academy of Sciences, 100(23), (Web Link)

[3] Cherry, J.M., Ball, C., Weng, S., Juvik, G., Schmidt, R., Adler, C., Dunn, B., Dwight, S., Riles, L., Mortimer, R.K. and Botstein, D., 1997. Genetic and physical maps of Saccharomyces cerevisiae. Nature, 387(6632 Suppl), (Web Link)

[4] Fermentation innovation through complex hybridization of wild and domesticated yeasts
Quinn K. Langdon, David Peris, EmilyClare P. Baker, Dana A. Opulente, Huu-Vang Nguyen, Ursula Bond, Paula Gonçalves, José Paulo Sampaio, Diego Libkind & Chris Todd Hittinger
Nature Ecology & Evolution volume 3, (Web Link)

[5] Morakinyo Sanni, D., Tosin Lawal, O. and Ola Salawu, S. (2018) “In silico Phylogenetics and Molecular Docking Studies of Rhodanese from Yeast (Saccharomyces cerevisiae)”, Journal of Advances in Biology & Biotechnology, 17(4), (Web Link)