News Release on Biochemistry Research: August-2018

American Society For Biochemistry And Molecular Biology Reacts To Stem-Cell Ruling

BETHESDA, Md., Sept. 2, 2010 — The yank Society for organic chemistry and biology expressed its disapproval and disappointment in the week in response to the Gregorian calendar month. twenty three ruling within the U.S. District Court for the District of Columbia that granted a preliminary injunction ejection federal funding of embryonic biological research.

In a statement, the society aforementioned the choice, that came in response to a proceedings filed by 2 adult stem-cell researchers, effectively halts human embryonic biological research within the u.  s. and “represents a crossroads in yank scientific policy.”

The society, that represents over twelve,000 scientists in each world and business worldwide, urged Congress to act fleetly to pass legislation that may restore federal funding to embryonic stem-cell researchers on not additional delay “potential medical cures for numerous sick Americans.” [1]

Secretory tumors of the pituitary gland: a clinical biochemistry perspective

The pituitary body is answerable for the assembly and/or secretion of varied hormones that play an important role in regulation endocrine perform inside the body. liquid body substance tumors of the anterior pituitary gland preponderantly, pituitary adenomas, together account for 10%–25% of central system tumors requiring operation. the foremost common liquid body substance tumors ar prolactinomas, which may be diagnosed by basal luteotropin levels. acromegalia are often diagnosed by basal hypoglycemic agent growth-like issue one levels and therefore the failure of internal secretion (GH) to suppress throughout associate oral aldohexose tolerance take a look at. brain doctor unwellness are often diagnosed by demonstrating hypercortisolemia proven by magnified secretion corticoid levels within the evening, magnified pee free corticoid excretion and failure of plasma corticoid to suppress following oral corticosteroid given nightlong (1.0 mg). we tend to conjointly discuss the diagnosing of the rarer thyrotropin and gonadotropin liquid body substance tumors. [2]

Yhe Effects of Resusciation Fluids on Hemodynamic Parameters and Blood Biochemistry of Rats Bled to Hypovolemia

INTRODUCTION: trauma shock could be a rare however serious complication which can result in hemodynamic instability, decrease in element delivery and faded tissue intromission, cellular drive, organ injury and death. Current study was designed to review the potency of blood, low mass starch answer (LWS) and hypertonic saline with dextrane (HSD) on hemodynamics parameters, curdling and tissue intromission of rats bled to hypovolaemia.

METHODS: Experiments were performed with Sprague Dawley rats (n=7 per group), advisement 200–250 g. The rats were bled through left arteria for twenty min in 3 sequential steps till the mean blood pressure fell to and stable at around twenty mmHg. Then animals in every cluster was treated either with HSD (4 ml/kg; i.v.) or LWS answer (4 ml/kg; i.v.) or keep blood transfusion (2 ml/100 g; i.v.) for half-hour.

RESULTS: In rats treated either with blood or HSD, the mean blood pressure values were found to be more than the rats treated with LWS answer. There was no vital distinction in pulse rate values among all 3 teams. LWS answer treatment adversely affected curdling (p<0.01) whereas no impact was recorded with HSD and blood treatments. [3]

Haematology and biochemistry of the San Cristóbal Lava Lizard (Microlophus bivittatus)

The San Cristóbal volcanic rock lizard, Microlophus bivittatus, is one in every of 9 species of volcanic rock lizards endemic to the Galapagos of Ecuador. No info presently exists regarding baseline health parameters for any of those species. we tend to analysed blood samples drawn from forty seven lizards (25 males and twenty {two} females) captured at two locations on San Cristóbal Island. a transportable blood instrument (iSTAT) was accustomed acquire near-immediate field results for total greenhouse gas, lactate, sodium, potassium, ionising Ca, aldohexose and haemoprotein. commonplace laboratory medical specialty techniques were utilized for differential white vegetative cell counts and haematocrit determination. blood heat, vital sign and body measurements were conjointly recorded. we tend to found vital variations in haematocrit values between males and females. The values reportable during this study give baseline information which will be helpful in sleuthing changes in health standing among volcanic rock lizards tormented by natural disturbances or anthropogenetic threats. [4]

Errors in Clinical Biochemistry Laboratory

Introduction: Clinical laboratories have centered their attention on internal control strategies and quality assessment programs handling analytical aspects of testing. however studies in recent years demonstrates that quality in clinical laboratories can’t be assured by just that specialize in analytical aspects. however mistakes occur additional oft before (pre-analytical) and once (post-analytical) the check has been performed. Objective of our study is to investigate the causes of errors occurring in our Clinical organic chemistry Laboratory and reason them, notice the frequency and proportion of errors.

Methodology: This study was dispensed during a fresh established Clinical organic chemistry laboratory.  Causes of errors were noted down and were categorised in to pre analytical, analytical and post analytical errors. knowledge has been noted down from Apr 2015 to December 2015.

Results: Pre analytical errors were conducive considerably to laboratory errors (59.8%) as compared to analytical (30.84%) and post-analytical errors (9.35%). Hemolyzed and thick samples were the most causes of pre analytical errors (37.5% and 21.87% respectively). activity drifts were conducive primarily to analytical errors (39.39%).Transcription error (60%) was the most contributor to the post analytical error. [5]

Reference

[1] American Society For Biochemistry And Molecular Biology Reacts To Stem-Cell Ruling

(web link)

[2]  Secretory tumors of the pituitary gland: a clinical biochemistry perspective

Gounden V, Rampursat YD, Jialal I. Secretory tumors of the pituitary gland: a clinical biochemistry perspective. Clinical Chemistry and Laboratory Medicine (CCLM). 2018 Aug 18. (web link)

[3] Yhe Effects of Resusciation Fluids on Hemodynamic Parameters and Blood Biochemistry of Rats Bled to Hypovolemia

Gül F, Ekinci O, Pelit T, Terzioğlu B, Bosna G, Erşahin M, Aydın N, Gören MZ. Yhe Effects of Resusciation Fluids on Hemodynamic Parameters and Blood Biochemistry of Rats Bled to Hypovolemia. The Medical Journal Of Haydarpaşa Numune Training and Research Hospital.;51(1):15-22. (web link)

[4] Haematology and biochemistry of the San Cristóbal Lava Lizard (Microlophus bivittatus)

Arguedas R, Steinberg D, Lewbart GA, Deresienski D, Lohmann KJ, Muñoz-Pérez JP, Valle CA. Haematology and biochemistry of the San Cristóbal Lava Lizard (Microlophus bivittatus). Conservation physiology. 2018 Aug 17;6(1):coy046. (web link)

[5] Errors in Clinical Biochemistry Laboratory

Usha Adiga1* and A. Preethika1

1Department of Biochemistry, KAiMS, Karwar, India. (web link)