News Update on Biochemistry Research: June – 2019

Practical clinical biochemistry.

It is rarely that a reviewer will trust the “commercial patter” on the dust cover of a technical book, and much too usually such advertisements will solely bring about to misanthropical laughter once the book is browse. This book will, however, be aforesaid to own lived up to the claim that it ought to be particularly valuable to all or any UN agency got to perform routine organic chemistry tests, i.e., to clinical pathologists, hospital biochemists, laboratory technicians, and to employees in university and different laboratories engaged in analysis work requiring the determination of chemical constituents of body fluids. The author provides a comprehensive assortment of these organic chemistry tests found most convenient for the hospital chemist. in a very few cases, quite one methodology may fairly are mentioned, however wherever the requirement is powerful (e.g. in glucose analyses that seven ways are given) he has not hesitated to relinquish different methods and infrequently discusses their intrinsic deserves. Summaries of the findings in health and illness are enclosed where fascinating.-D. S. PAPWORTH. [1]

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

Lipid peroxidation usually happens in response to aerobic  stress, and a good diversity of aldehydes ar shaped once lipoid hydroperoxides break down in biological systems. a number of these aldehydes ar extremely reactive and should be thought of as second toxicant messengers that publicise and augment initial atom events. The aldehydes most intensively studied thus far ar 4-hydroxynonenal, 4-hydroxyhexenal, and malonaldehyde. the aim of this review is to produce a comprehensive outline on the chemical properties of those aldehydes, the mechanisms of their formation and their incidence in biological systems and ways for his or her determination. we are going to additionally review the reactions of 4-hydroxyalkenals and malonaldehyde with biomolecules (amino acids, proteins, supermolecule bases), their metabolism in isolated cells and excretion in whole animals, further because the many sorts of biological activities delineated  thus far, as well as toxicity, genotoxicity, chemotactic, and effects on cell proliferation and organic phenomenon. Structurally connected compounds, like aldehyde, crotonaldehyde, and alternative 2-alkenals also are in brief mentioned, since they need some properties in common with 4-hydroxyalkenals. [2]

RHO GTPASES: Biochemistry and Biology

Approximately simple fraction of the human ordination encodes proteins that either regulate or are regulated by direct interaction with members of the alphabetic character family of tiny GTPases. Through a series of complicated organic chemistry networks, these extremely preserved molecular switches management a number of the foremost elementary processes of cell biology common to all or any eukaryotes, together with ontogeny, polarity, movement, and cellular division. within the 1st a part of this review, we tend to gift the most effective characterised of those organic chemistry pathways; within the second half, we tend to arrange to integrate these molecular details into a biological context. [3]

Blood Biochemistry Analysis to Detect Smoking Status and Quantify Accelerated Aging in Smokers

There is AN association between smoking and cancer, upset and all-cause mortality. However, currently, there are not any cheap and informative tests for assessing the results of smoking on the speed of biological aging. during this study we tend to demonstrate for the primary time that smoking standing are often expected mistreatment blood organic chemistry and cell count results andthe recent advances in AI (AI). By using age-prediction models developed mistreatment supervised deep learning techniques, we tend to found that smokers exhibited higher aging rates than nonsmokers, no matter their sterol ratios and fast aldohexose levels. we tend to additional used those models to quantify the acceleration of biological aging because of tobacco use. feminine smokers were expected to be double as recent as their age compared to nonsmokers, whereas male smokers were expected to be one and a [*fr1] times as recent as their age compared to nonsmokers. Our findings counsel that deep learning analysis of routine blood tests may complement or perhaps replace the present fallible methodology of self-reporting of smoking standing and will be enlarged to assess the impact of different manner and environmental factors on aging. [4]

Effect of Helicobacter pylori Infection on Selected Biochemical Parameters of Hypertensive Patients at Dschang District Hospital in Cameroon

Aims: Helicobacter pylori infection is a very important explanation for ulcer illness and alternative epithelial duct disorders. The rubor caused by H. pylori results in macromolecule metabolism disorders that will act as risk factors for hypertensive patients. The aim of the study was to hunt for doable correlation between H. pylori immune globulin seropositivity and also the variations of some organic chemistry parameters amongst hypertensive patients within the District Hospital of Dschang.

Place and period of Study: Department of organic chemistry and District Hospital of Dschang, between November 2015 to March 2016.

Methods: we tend to conducted a cross-sectional study from November 2015 to March 2016 consecutively enrolling one hundred twenty five willing patients of average age fifty four.36 ± eight years attending the hospital for medical check-up. 2 pressure level measurements and also the determination of immune globulin anti  H. pylori by the indirect enzyme-linked immunosorbent assay (ELISA) technique, enabled US to tell apart four teams of patients: hypertensive (HT+), H. pylori immune globulin seropositive (HP+), H. pylori immune globulin seropositive and hypertensive (HT+HP+), and a gaggle of patients free from the 2 pathologies (HT-HP -). Measurements of organic chemistry parameters like total steroid alcohol, HDL cholesterol, LDL cholesterol, triglycerides, creatinine, CRP, aldohexose and albumen were drained serum/plasma by strategies ensuing from business kits.

Results: Analysis of organic chemistry knowledge showed important elevated levels (p < zero.05) of total steroid alcohol, creatinine, albumen and LDL cholesterol levels within the teams HT+ and HT+HP+ compared to the cluster of HT-HP -. Moreover, average rate of HDL cholesterol was considerably lower within the teams HT+, HT+HP+ and HP+ compared to the management cluster (HT-HP-). Abnormal high elevated levels of LDL cholesterol, HDL cholesterol, total steroid alcohol, trigylcerides, CRP and creatinine were determined within the teams HT+HP+, HP+ and HT+ as compared to the cluster HT-HP-.

Conclusions: Our findings recommend a big association between H. pylori immune globulin seropositivity and cardiovascular disease and also the joint effects of those 2 diseases on sure organic chemistry parameters studied. These results represent an artless contribution within the observance and handling the studied pathologies. [5]


[1] Varley, H., 1954. Practical clinical biochemistry. Practical clinical biochemistry. (Web Link)

[2] Esterbauer, H., Schaur, R.J. and Zollner, H., 1991. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free radical Biology and medicine, 11(1), pp.81-128. (Web Link)

[3] Jaffe, A.B. and Hall, A., 2005. Rho GTPases: biochemistry and biology. Annu. Rev. Cell Dev. Biol., 21, pp.247-269. (Web Link)

[4] Blood Biochemistry Analysis to Detect Smoking Status and Quantify Accelerated Aging in Smokers

Polina Mamoshina, Kirill Kochetov, Franco Cortese, Anna Kovalchuk, Alexander Aliper, Evgeny Putin, Morten Scheibye-Knudsen, Charles R. Cantor, Neil M. Skjodt, Olga Kovalchuk & Alex Zhavoronkov

Scientific Reportsvolume 9, Article number: 142 (2019) (Web Link)

[5] Tamokou, J.- de-D., Tonleu Guimtsop, Y. A., Ndebi, M. E., Linda Nzesseu, V., Djokge, A. K. and Kuiate, J.-R. (2017) “Effect of Helicobacter pylori Infection on Selected Biochemical Parameters of Hypertensive Patients at Dschang District Hospital in Cameroon”, International Journal of TROPICAL DISEASE & Health, 26(1), pp. 1-8. doi: 10.9734/IJTDH/2017/36252. (Web Link)