News Update on Cancer Metastasis Research: April – 2019

Loss of exosomal miR‐148b from cancer‐associated fibroblasts promotes endometrial cancer cell invasion and cancer metastasis

Cancer‐associated fibroblasts (CAFs) play crucial roles in tumour progression, given the dependence of cancer cells on stromal support. Therefore, understanding however CAFs communicate with carcinoma cell in tumour surroundings is very important for endometrial cancer medical aid. Exosomes, that contain proteins and noncoding ribonucleic acid, are known as a very important go-between of cell–cell communication. However, the operate of exosomes in carcinoma metastasis remains poorly understood. within the current study we tend to found that CAF‐derived exosomes considerably promoted carcinoma cell invasion examination to those from traditional fibroblasts (NFs). we tend to known a big decrease of miR‐148b in CAFs and CAFs‐derived exosomes. By exogenously transfect microRNAs, we tend to incontestible that miR‐148b may well be transferred from CAFs to carcinoma cell through exosomes. In vitro and in vivo studies additional disclosed that miR‐148b functioned as a tumour suppressor by directly binding to its downstream target factor, DNMT1 to suppress carcinoma metastasis. In carcinoma DNMT1 given a possible role in enhancing neoplastic cell metastasis by causation epithelial–mesenchymal transition (EMT). Therefore, downregulated miR‐148b elicited EMT of carcinoma cell as a results of relieving the suppression of DNMT1. Taken along, these results recommend that CAFs‐mediated carcinoma progression is part associated with the loss of miR‐148b within the exosomes of CAFs and promoting the transfer of stromal cell‐derived miR‐148b can be a possible treatment to stop endometrial cancer progression. [1]

Circular RNA circMTO1 suppresses bladder cancer metastasis by sponging miR-221 and inhibiting epithelial-to-mesenchymal transition

Bladder cancer remains a number one reason behind cancer-related death thanks to its distant metastasis and high repeat rates. liberation of circular RNAs (circRNAs) will act either as tumour suppressors or oncogenes to manage cell proliferation, migration, and metastasis. The role of circMTO1 in bladder cancer stay unknown. during this study, we have a tendency to investigated whether or not circMTO1 may use as a biomarker and therapeutic target for bladder cancer treatment. we have a tendency to 1st incontestible that circMTO1 was a very important circRNA oftentimes downregulated in bladder cancer tissue, and lower circMTO1 levels were absolutely related to with bladder cancer patients’ metastasis and poorer survival. position expression of circMTO1 in bladder cancer cells suppressed cell’s epithelial-to-mesenchymal transition (EMT) and metastasis. additionally, we have a tendency to conjointly discovered that circMTO1 was ready to sponge miR-221 and overexpression of circMTO1 negatively regulated the E-cadherin/N-cadherin pathway to inhibit bladder cancer cells’ EMT by competitory for miR-221. finally, our findings offer comprehensive evidences that circMTO1 may be a prognostic biomarker in bladder cancer and recommend that circMTO1 could operate as a unique therapeutic target in human bladder cancer.[2]

Tumor-derived exosomes in cancer metastasis risk diagnosis and metastasis therapy

Exosomes are endosomes secreted from the membrane by exocytosis as multivesicular bodies and are typically outlined by their spherical, unilamellar morphology, size and also the expression of specific biomarkers used for diagnosing or medical aid targets. Recent analysis has reportable a better relationship between exosome enrichment and tumour malady development. during this review, we tend to discuss exosome living thing communication and functions within the

pathology of malady, particularly on the cancer metastasis connected with exosome. we tend to introduce however exosomes from cancer and stem cancer cells target completely different organs through transporting molecular proteins of exosome inclusions to enhance or inhibit cancer metastasis moreover as highlight exosome medical aid ways for tumour pathology involving microRNAs. [3]

Glucocorticoids promote breast cancer metastasis

Diversity at intervals or between neoplasms and metastases (known as intra-patient tumour heterogeneity) that develops throughout illness progression could be a serious hurdle for therapy1,2,3. Metastasis is that the fatal hallmark of cancer and therefore the mechanisms of constitution, the foremost complicated step within the pathological process cascade4, stay poorly outlined. A clearer understanding of the cellular and molecular processes that underlie each intra-patient neoplasm heterogeneousness and metastasis is crucial for the success of customized cancer medical aid. Here, exploitation transcriptional identification of tumours and matched metastases in patient-derived graft models in mice, we have a tendency to show cancer-site-specific phenotypes and accrued endocrine receptor activity in distant metastases. The endocrine receptor mediates the results of stress hormones, and of artificial derivatives of those hormones that are used wide within the clinic as medicine and immunological disorder agents. we have a tendency to show that the rise in stress hormones throughout carcinoma progression ends up in the activation of the endocrine receptor at distant pathological process sites, accrued constitution and reduced survival. Our transcriptomics, genetic science and phospho-proteomics studies implicate the endocrine receptor within the activation of multiple processes in metastasis and in the accrued expression of enzyme ROR1, each of that correlate with reduced survival. The ablation of ROR1 reduced pathological process outgrowth and prolonged survival in diagnosing models. Our results indicate that the activation of the endocrine receptor will increase heterogeneousness and metastasis, that suggests that caution is required once exploitation glucocorticoids to treat patients with carcinoma United Nations agency have developed cancer-related complications. [4]

Prostanoids and Their Mediated Inflammatory Responses in Lung Cancer

Prostanoids are biochemically vital molecules with vital roles in pain and inflammatory responses. These responses are studied in many processes of cancer development, together with carcinoma. The aim of this text is to review the present literature on the inflammatory responses in carcinoma mediate by prostanoids. info concerning totally different categories of prostanoids, carcinoma and their incidence are mentioned. withal, the review additionally covers recent info on roles of prostanoids in carcinoma development and its risk issue. [5]


[1] Li, B.L., Lu, W., Qu, J.J., Ye, L., Du, G.Q. and Wan, X.P., 2019. Loss of exosomal miR‐148b from cancer‐associated fibroblasts promotes endometrial cancer cell invasion and cancer metastasis. Journal of cellular physiology, 234(3), pp.2943-2953. (Web Link)

[2] Li, Y., Wan, B., Liu, L., Zhou, L. and Zeng, Q., 2019. Circular RNA circMTO1 suppresses bladder cancer metastasis by sponging miR-221 and inhibiting epithelial-to-mesenchymal transition. Biochemical and biophysical research communications, 508(4), pp.991-996. (Web Link)

[3] Jiang, S., Hu, C., Liu, P. and Lu, M., 2019. Tumor-derived exosomes in cancer metastasis risk diagnosis and metastasis therapy. Clinical and Translational Oncology, 21(2), pp.152-159. (Web Link)

[4] Glucocorticoids promote breast cancer metastasis

Milan M. S. Obradović, Baptiste Hamelin, Nenad Manevski, Joana Pinto Couto, Atul Sethi, Marie-May Coissieux, Simone Münst, Ryoko Okamoto, Hubertus Kohler, Alexander Schmidt & Mohamed Bentires-Alj

Naturevolume 567, pages540–544 (2019) (Web Link)

[5] Ohwofasa, A., Aliyu, A. and Sheshe, S. (2018) “Prostanoids and Their Mediated Inflammatory Responses in Lung Cancer”, International Journal of Biochemistry Research & Review, 23(3), pp. 1-10. doi: 10.9734/IJBCRR/2018/43911. (Web Link)