Cysteine-Based Redox Sensing and Its Role in Signaling by Cyclic Nucleotide–Dependent Kinases in the Cardiovascular System

Oxidant molecules are made in biological systems and traditionally are thought-about causative mediators of harm and unwellness. whereas oxidants might contribute to the pathological process of unwellness, proof continues to emerge that shows these species additionally play necessary regulative roles in health. a significant mechanism of oxidiser sensing and sign involves their reaction with reactive aminoalkanoic acid thiols inside proteins, causing aerophilic posttranslational modifications that may couple to altered perform to alter physiological condition regulation. macromolecule enzyme A and protein kinase G are regulated by oxidants during this approach, and this review focuses on our molecular-level understanding of those events and their role in regulation vessel physiology throughout health and unwellness. [1]

Transportation noise linked to cardiovascular disease independent from air pollution

Air pollution and traffic noise are the 2 major environmental pollutants moving health per the globe Health Organization (WHO).1 For pollution, the yank Heart Association ended already in 2010 that ‘the overall proof is in keeping with a causative relationship between material (PM2.5) exposure and vessel morbidity and mortality’.2 However, at the time of the review there have been solely few studies that enclosed… [2]

A Theory-Driven System for the Specification of Rehabilitation Treatments

The field of rehabilitation remains captive to the black-box problem: our inability to characterize treatments during a systematic fashion across diagnoses, settings, and disciplines, therefore on determine and pass around the active ingredients of these treatments. during this article, we tend to describe the Rehabilitation Treatment Specification System (RTSS), by that any treatment utilized in rehabilitation is also characterised, and ultimately classified consistent with shared properties, via the three parts of treatment theory: targets, ingredients, and (hypothesized) mechanisms of action. we tend to discuss necessary ideas within the RTSS like the excellence between treatments and treatment parts, that include one target and its associated ingredients; and also the distinction between targets, that are the direct effects of treatment, and aims, that are downstream or distal effects. The RTSS includes three teams of reciprocally exclusive treatment components: Organ Functions, Skills and Habits, and Representations. The last of those includes not solely thoughts and feelings, however conjointly internal representations underlying willing  action; the RTSS addresses the thought of volition (effort) as a essential component for several rehabilitation treatments. we’ve got developed associate algorithmic program for treatment specification that is illustrated and represented in short. The RTSS stands to profit the sphere in varied ways in which by provision a coherent, theoretic framework encompassing all rehabilitation treatments. employing a common framework, researchers are going to be able to take a look at consistently the results of specific ingredients on specific targets; and their work will be additional without delay replicated and translated into clinical observe.[3]

Circadian rhythms and the molecular clock in cardiovascular biology and disease

The Earth turns on its axis every 24 h; almost all life on the planet has a mechanism — circadian rhythmicity — to anticipate the daily changes caused by this rotation. The molecular clocks that control circadian rhythms are being revealed as important regulators of physiology and disease. In humans, circadian rhythms have been studied extensively in the cardiovascular system. Many cardiovascular functions, such as endothelial function, thrombus formation, blood pressure and heart rate, are now known to be regulated by the circadian clock. Additionally, the onset of acute myocardial infarction, stroke, arrhythmias and other adverse cardiovascular events show circadian rhythmicity. In this Review, we summarize the role of the circadian clock in all major cardiovascular cell types and organs. Second, we discuss the role of circadian rhythms in cardiovascular physiology and disease. Finally, we postulate how circadian rhythms can serve as a therapeutic target by exploiting or altering molecular time to improve existing therapies and develop novel ones. [4]

Fixed Doses Combinations Acting on Cardiovascular System – Utilization and Generic Competition

Aims: to research the impact of introduction of latest mounted dose combos (FDCs) within the Positive drug list on each the reference value and also the utilization of reimbursed vas (CV) medicines.

Study Design: it’s a retrospective and empiric analysis of the changes in reimbursed mounted dose combos (FDCs) performing on vascular system (CVS).

Place and length of Study: Medical University of Sofia, school of Pharmacy for the amount 2009-2013.

Methodology: On total eighteen INNs (international unpatented name) in several combos happiness to six anatomic therapeutic chemical (ATC) teams (ACE-inhibitor and diuretic drug, Ca-antagonists and ACE-inhibitors, sartan and diuretics, Ca-antagonist and statin drug, 2 diuretics, b-blocker and diuretic); sixty indefinite quantity forms, and 104 emblems were analyzed for changes within the costs and utilization when the inclusion in the Positive drug list (PDL).

Results: the quantity of the new generic medicines enclosed in force unit is highest for the cluster of ACE -inhibitors and diuretics, Hypertensin receptor blockers (AT receptor blockers, ARBs, sartans) and diuretics. several new generic molecules as FDCs enter the force unit, so resulting in decrease within the reference value, due to generic competition. The decrease is critical within the new therapeutic teams. The changes in utilization calculated as outlined daily dose (DDD)/1000 inhabitants/day show higher utilization in 2013 for the teams of ACE inhibitors and diuretics and AT receptor blockers and diuretics (Enalapril/ Hydrochlorthiazide (HCTZ), Perindopril/ diuretic drug, Valsartan/HCTZ, Losartan/ HCTZ).

Conclusion: The study confirms that in Bulgaria the generic and therapeutic competition has multiplied throughout 2009-2013. It results in important value decrease and changes within the trends in utilization of the FDC in medicine. [5]


[1] Cuello, F. and Eaton, P., 2019. Cysteine-Based Redox Sensing and Its Role in Signaling by Cyclic Nucleotide–Dependent Kinases in the Cardiovascular System. Annual review of physiology81, pp.63-87. (Web Link)

[2] Sørensen, M. and Pershagen, G., 2019. Transportation noise linked to cardiovascular disease independent from air pollution. European heart journal. (Web Link)

[3] Hart, T., Dijkers, M.P., Whyte, J., Turkstra, L.S., Zanca, J.M., Packel, A., Van Stan, J.H., Ferraro, M. and Chen, C., 2019. A theory-driven system for the specification of rehabilitation treatments. Archives of physical medicine and rehabilitation100(1), pp.172-180. (Web Link)

[4] Circadian rhythms and the molecular clock in cardiovascular biology and disease

Sandra CrnkoBastiaan C. Du PréJoost P. G. Sluijter & Linda W. Van Laake Nature Reviews Cardiology (2019) (Web Link)

[5] Mitkova, Z., Manova, M., Georgieva, S. and Petrova, G. (2016) “Fixed Doses Combinations Acting on Cardiovascular System – Utilization and Generic Competition”, Advances in Research, 8(2), pp. 1-14. doi: 10.9734/AIR/2016/29264. (Web Link)

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