Problems with precaution: the transfusion medicine experience

The preventative principle could be a dominant paradigm governing risk-based decision-making. Today, there are increasing pressures to re-examine aggressive preventative approaches, and to assess however the principle ought to be applied within the trendy system. during this paper, we have a tendency to examined 3 key applications of preventative approaches within the field of transfusion medication to produce insight into the risks and advantages of those approaches. The 3 case studies examined were the donor deferral policies to safeguard against transfusion transmission of human immunological disorder virus, variant Creutzfeldt–Jacob sickness, and, lastly, xenotropic murine malignant neoplastic disease virus-related virus. Characterization of preventative applications was conducted mistreatment associate embedded case study style. Our findings indicate that transfusion transmission mitigation ways became more and more aggressive within the face of theoretical risks. In distinction, the review processes for implementation and reversal of preventative policies are slow, and historical donor deferral policies are still in situ nowadays. Application of preventative approaches has tried difficult with each advantages and pitfalls. In light-weight of rising threats to the blood system, policy-makers ought to contemplate the implementation of frameworks to guide the suitable application of precaution in transfusion medication within the future. [1]

Assessment of the knowledge and perceptions of Brazilian medical residents on transfusion medicine


Medical education contains a major social impact as a result of it ultimately influences the standard and safety of the health service offered to the population. many studies have acknowledged the connection between medical information on transfusion medication and also the correct use of this medical care. The rational use of blood has become a worldwide concern. during this context, the aim of the current study was to guage medical residents’ information on transfusion medication in hospitals settled in Rio {de Janeiro|Rio|city|metropolis|urban center} de Janeiro, Brazil, and their coaching throughout their medical education.


One hundred and 6 residents from eight medical specialties of 4 hospitals participated. A form developed by the medical specialty Excellence for Safer Transfusion (BEST) cluster was applied to guage the participants’ medical information. Another form was additionally applied to guage participant profiles concerning frequency of transfusion prescriptions, self-perceived information and relevancy of the topic.


The mean variety of correct answers to the form on information regarding transfusion practices was forty three.5% (range: 15–80%). A relationship between coaching throughout medical residency and also the obtained result was ascertained (p-value = zero.0007). Most residents (73%) failed to receive coaching in transfusion medication throughout their graduation or residency and ninety three would love to receive further training.


A clear deficit within the information of transfusion medication was verified, indicating the requirement for amendment within the teaching of this specialty. This result’s kind of like some developed countries. [2]

Febrile Nonhemolytic Transfusion Reactions

Febrile nonhemolytic transfusion reactions (FNHTRs) are ordinarily encountered transfusion reactions with overall per unit rate of 1%–3%. FNHTR manifests as fever and/or chills while not haemolysis occurring within the patient throughout or at intervals four hours of stop of transfusion, and also the diagnosing is formed by excluding different causes of fever. the foremost common explanation for FNHTRs thanks to passively transfused cytokines or recipient antibodies reacting with leukocytes within the blood product. The rumored incidence of FNHTRs varies wide, and better rates are seen with nonleukoreduced protoplasm and red vegetative cell (RBC) transfusions. Most reactions are straightforward to manage and might be prevented by prestorage white blood cell reduction of blood merchandise, that is effective in preventing reactions to each RBCs and platelets. FNHTRs are often a burden on each patient and hospital. [3]

One size will never fit all: the future of research in pediatric transfusion medicine

There is concern at the National Heart, Lung, and Blood Institute (NHLBI) and among transfusion drugs specialists concerning the little range of investigators and studies within the field of medical specialty transfusion medicine (PTM). consequently, the target of this text is to produce a shot of the clinical and change of location PTM analysis thought of to be of high priority by pediatricians, neonatologists, and transfusion drugs specialists. enclosed could be a targeted review of 3 analysis areas of importance: (i) transfusion ways, (ii) short- and long clinical consequences, and (iii) transfusion-transmitted infectious diseases. The recommendations by PTM and transfusion drugs specialists represent opportunities and innovative ways to execute change of location analysis, experimental studies, and clinical trials of high connectedness to PTM. With the explosion of latest medical specialty data and progressively refined methodologies over the past decade, this is often associate exciting time to think about transfusion drugs as a paradigm for addressing queries associated with fields like cell biology, immunology, neurodevelopment, outcomes analysis, and lots of others. enlarged awareness of PTM as a vital, fertile field and also the promotion of incidental to opportunities can facilitate establish PTM as a viable career possibility and advance basic and clinical investigation to enhance the health and well-being of kids. [4]

Quality Assurance and Quality Control in a Bottle Manufacturing Company Using Statistical Quality Control

The present paper aimed to research the analysis of quality losses within the producing method of fifty cl R/Spirit bottles victimisation applied math internal control technique. The analysis coated the factors that have an effect on the standard of the glass bottles and the way the assembly method will be optimized to attenuate defects. the information obtained from our investigation hub for thirteen days was with success analyzed victimisation internal control charts and Taguchi quality loss operate. The Taguchi quality loss operate was with success utilized to calculate quality loss. The loss incurred thanks to defects was N25, 636.84. Results obtained from  chart and chart showed that the producing method was out of management as some points fell outside the control limits. The attainable causes of variations were known and eliminated. This crystal rectifier to a discount within the range of defective bottles created per batch of production. The common causes of defects and deviations from target values were thanks to imperfectness within the production method, traceable to the operators, machine and inappropriate proportion of raw materials. [5]


[1] Wilson, K., Atkinson, K.M., Fergusson, D.A., Brown, A., Forster, A., Murphy, M.S., Tinmouth, A.T. and Keelan, J., 2019. Problems with precaution: the transfusion medicine experience. Journal of risk research, 22(2), pp.137-149. (Web Link)

[2] de Vasconcelos Vaena, M.M. and Alves, L.A., 2019. Assessment of the knowledge and perceptions of Brazilian medical residents on transfusion medicine. Hematology, transfusion and cell therapy, 41(1), pp.37-43. (Web Link)

[3] Maramica, I., 2019. Febrile Nonhemolytic Transfusion Reactions. In Transfusion Medicine and Hemostasis (pp. 385-388). Elsevier. (Web Link)

[4] One size will never fit all: the future of research in pediatric transfusion medicine

Cassandra D. Josephson, Traci Heath Mondoro, Daniel R. Ambruso, Rosa Sanchez, Steven R. Sloan, Naomi L. C. Luban & John A. Widness

Pediatric Research volume 76, pages 425–431 (2014) (Web Link)

[5] E. Odinikuku, W. (2018) “Quality Assurance and Quality Control in a Bottle Manufacturing Company Using Statistical Quality Control”, Journal of Materials Science Research and Reviews, 1(2), pp. 1-8. Available at: (Accessed: 29April2019). (Web Link)

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