Latest News on Retinopathy Research: Dec – 2019

The International Classification of Retinopathy of Prematurity revisited.

The International Classification of Retinopathy of immaturity (ICROP) was revealed in two components, the primary in 1984 and later distended in 1987. it had been a agreement statement of a global cluster of retinopathy of immaturity specialists. the first classification has expedited the event of huge multicenter clinical treatment trials and furthered our understanding of this probably blazing disorder. With improved imaging techniques within the nursery, we have a tendency to area unit able to supply a a lot of quantitative approach to a number of the characteristics delineated  within the ICROP. a global cluster of paediatric ophthalmologists and retinal specialists has developed a agreement document that revises some aspects of ICROP. Few modifications were felt to be required. [1]

Hypertensive Retinopathy

This review explains the pathophysiological changes that elevated force per unit area produces within the retinal circulation. Recent studies show that some specific retinal signs area unit robust predictors of stroke, freelance of elevated force per unit area. distinguishing the degree of retinopathy will facilitate clinicians to deliver best treatment and forestall upset and death. [2]

Retinopathy of prematurity

Retinopathy of prematureness (ROP) may be a common glaring unwellness in youngsters within the developed world despite current treatment, and is changing into progressively prevailing within the developing world. ROP progresses in 2 phases. the primary section begins with delayed retinal tube growth when birth and partial regression of existing vessels, followed by a second section of hypoxia-induced pathological vessel growth. 2 major risk factors of ROP area unit the utilization of element and a shrunken biological time. Excessive element contributes to ROP through regulation of tube epithelium protein (VEGF). Suppression of VEGF by element in phase I of ROP inhibits traditional vessel growth, whereas elevated levels of VEGF induced  by drive in clinical test of ROP precipitate pathological vessel proliferation. [3]

Vascular changes in diabetic retinopathy—a longitudinal study in the Nile rat

Diabetic retinopathy is that the commonest microvascular complication of polygenic disorder and may be a major explanation for cecity, however Associate in Nursing understanding of the pathologic process of the illness has been hampered by an absence of correct animal models. Here, we have a tendency to explore the dynamics of retinal cellular changes within the river rat (Arvicanthis niloticus), a carbohydrate-sensitive model for sort two polygenic disorder. the first retinal changes in diabetic river rats enclosed multiplied noncellular  capillaries and loss of pericytes that related  linearly with the period of polygenic disorder. These tube-shaped structure changes occurred within the presence of microglial infiltration however within the absence of retinal neural structure cell loss. [4]

Possible Biochemical Abnormalities of Plasma Lipids and Apo-lipoprotein in Diabetes mellitus Patients with or without Retinopathy In Saki- West Local Government Area of Oyo State- Nigeria

Study Background: potential metabolic disorders of supermolecule, supermolecule and supermolecule area unit related to DM which can embrace complications like retinopathy considering the pathophysiology of this metabolic illness.

Aims and Objectives: This work was designed to see apolipoproteins (ApoA, ApoB), Total cholesterin (TC), Total glyceride (TG), LDL (LDL-C), terribly LDL (VLDL), lipoprotein (HDL-C) in DM patients with or while not retinopathy. [5]

Reference

[1] International Committee for the Classification of Retinopathy of Prematurity, 2005. The international classification of retinopathy of prematurity revisited. Archives of Ophthalmology (Chicago, Ill.: 1960), 123(7), (Web Link)

[2] Wong, T.Y. and Mitchell, P., 2004. Hypertensive retinopathy. New England Journal of Medicine, 351(22), (Web Link)

[3] Chen, J. and Smith, L.E., 2007. Retinopathy of prematurity. Angiogenesis, 10(2), (Web Link)

[4] Vascular changes in diabetic retinopathy—a longitudinal study in the Nile rat
Huishi Toh, Alexander Smolentsev, Rachel V. Bozadjian, Patrick W. Keeley, Madison D. Lockwood, Ryan Sadjadi, Dennis O. Clegg, Barbara A. Blodi, Peter J. Coffey, Benjamin E. Reese & James A. Thomson
Laboratory Investigation volume 99, (Web Link)

[5] Folaranmi Olaniyan, M., Akanji Popoola, O., Priscilla Olasupo, O., Afolabi, T. and Gbenga Olayinka, S. (2018) “Possible Biochemical Abnormalities of Plasma Lipids and Apo-lipoprotein in Diabetes mellitus Patients with or without Retinopathy In Saki- West Local Government Area of Oyo State- Nigeria”, International Journal of Biochemistry Research & Review, 21(1), (Web Link)