Abstract The important component of obesity pathogenesis is inflammatory activation of innate immune cells within adipose tissue and in other body locations. Both the course of obesity and innate immune reactivity are characterized by sex-associated differences. The aim of the work was a comparative investigation of metabolic profiles of phagocytes from different locations in male
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An injectable gel-like scaffold can hold combination chemo-immunotherapeutic drugs and deliver them locally and sequentially to tumors. The results in animal models so far suggest this approach could eventually ramp up therapeutic benefits for patients bearing tumors or after removal of the primary tumors. The research, published in Science Translational Medicine, focused on two specific types
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Fig. 4 (modified from Ezzyat et al., 2018). Stimulation targets showing numerical increase/decrease in free recall performance are shown inred/blue. Memory-enhancing sites clustered in the middle portion of the left middle temporal gyrus. Everyone forgets. As we grow older or have a brain injury or a stroke or develop a neurodegenerative disease, we forget much more often. Is there
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Human beings have existed on Earth for nearly 200,000 years, and none of the many pathogens or natural disasters they faced has succeeded in wiping them out. So, worrying about humanity’s vulnerability to a strain of bacteria, superbugs or a virus seems like irrational pessimism. It’s pessimistic, certainly, but it’s not irrational. Few people realize
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The Health Research Alliance today announced a new application called “HRA Open” powered by Figshare. HRA Open will allow HRA member-funded awardees to link their awards to their research outputs and deposit publications into PubMed Central. HRA Open is an HRA-sponsored web-based service that promotes open science by providing a space for awardees to upload and
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