Latest News on Emblica Officinalis : March -2020

Antitumour activity of Emblica officinalis

Aqueous extract of Emblica officinalis (E.O) was found to be cytotoxic to L 929 cells in culture in a dose dependent manner. Concentration needed for 50% inhibition was found to be 16.5 μg/ml. E.O and chyavanaprash (a non-toxic herbal preparation containing 50% E.O) extracts were found to reduce ascites and solid tumours in mice induced by DLA cells. [1]

Flavonoids from Emblica officinalis and Mangifera indica—effectiveness for dyslipidemia

Flavonoids from Emblica officinalis and Mangifera indica effectively reduce lipid levels in serum and tissues of rats induced hyperlipidemia. Hepatic HMG CoA reductase activity was significantly inhibited in rats fed E. officinalis flavonoids. [2]

Hepatoprotective activity of Emblica officinalis and Chyavanaprash

Hepatoprotective activity of Emblica officinalis (EO) and Chyavanaprash (CHY) extracts were studied using carbon tetrachloride (CCl4) induced liver injury model in rats. EO and CHY extracts were found to inhibit the hepatotoxicity produced by acute and chronic CCl4 administration as seen from the decreased levels of serum and liver lipid peroxides (LPO), glutamate-pyruvate transaminase (GPT), and alkaline phosphatase (ALP). [3]

Amelioration Effect of Emblica officinalis Extract on Ovary in Endosulfan Induced Swiss Albino Mice

Background: In the present time use of pesticides has become very common by the farmers for the better yield of crops. Endosulfan, a chlorinated cyclodiene insecticide, is widely and very liberally used in agricultural sector. But it has created deleterious effects on human health. Objective: In the present study amelioration effect of Emblica officinalis (E. officinalis) extract on ovary in Endosulfan induced Swiss albino mice was studied. Materials and Methods: Three groups were formed, each with [4]

Emblica officinalis Stimulates the Secretion and Action of Insulin and Inhibits Starch Digestion and Protein Glycation In vitro

Aim: Medicinal, edible and aromatic plants and natural products have been used worldwide for the management of diabetes mellitus. The aim of this study was to investigate the efficacy and mode of action of Emblica officinalis Gaertn. (Phyllanthaceae) used traditionally for treatment of diabetes. Study Design: Using multiple In vitro models; this study was designed to investigate the antidiabetes efficacy and mode of action of E. officinalis. [5]

[1] Jose, J.K., Kuttan, G. and Kuttan, R., 2001. Antitumour activity of Emblica officinalis. Journal of Ethnopharmacology, 75(2-3), pp.65-69.

[2]Anila, L. and Vijayalakshmi, N., 2002. Flavonoids from Emblica officinalis and Mangifera indica—effectiveness for dyslipidemia. Journal of Ethnopharmacology, 79(1), pp.81-87.

[3] Jose, J.K. and Kuttan, R., 2000. Hepatoprotective activity of Emblica officinalis and Chyavanaprash. Journal of Ethnopharmacology, 72(1-2), pp.135-140.

[4] Sinha, P. and Kumari, A., 2016. Amelioration Effect of Emblica officinalis Extract on Ovary in Endosulfan Induced Swiss Albino Mice. Journal of Pharmaceutical Research International, pp.1-9.

[5] Kasabri, V., Flatt, P.R. and Abdel-Wahab, Y.H.A., 2014. Emblica officinalis stimulates the secretion and action of insulin and inhibits starch digestion and protein glycation in vitro. European Journal of Medicinal Plants, pp.753-770.