Aim: To investigate the hepatoprotective activity of Morus alba Linn. leaves extracts against carbon tetrachloride (CCl4) induced hepatotoxicity. Materials and Methods: Leaves powder of Morus alba was successively extracted with petroleum ether extract (PEE), chloroform extract (CHE), alcoholic extract (ALE) and water extract (AQE) against carbon tetrachloride (CCl4) induced hepatotoxicity and using Standard drug is Liv-52. Preliminary phytochemical tests were done. Results: The ALE showed presence of alkaloids, flavonoides, carbohydrates, tannins and steroids, while carbohydrates, flavonoides, alkaloids were present with AQE. The PEE, CHE, ALE did not produce any mortality. Carbon tetrachloride produced significant changes in biochemical parameters (increases in serum glutamate pyruvate transaminase (SGPT), Serum glutamate oxaloacetate transaminase (SGOT), alanine phosphatase (ALP) and serum bilirubin.), histological (damage to hepatocytes). using Standard drug Liv-52. Pretreatment with ALE and AQE extracts significantly prevented the biochemical and histological changes induced by CCl4 in the liver. Conclusion: The present study that shows the ALE and AQE extracts possessed hepatoprotective activity.
Dr. M. G. Hogade,
Department of Pharmacognosy and Phytochemistry, VDF School of Pharmacy, Latur, Maharashtra, India.
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